7ZK8
ABCB1 L971C mutant (mABCB1) in the outward facing state bound to AAC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ATP-dependent translocase ABCB1 | polymer | 1271 | 140198.9 | 1 | UniProt (P21447) Pfam (PF00664) Pfam (PF00005) | Mus musculus (house mouse) | ATP-binding cassette sub-family B member 1A,MDR1A,Multidrug resistance protein 1A,Multidrug resistance protein 3,P-glycoprotein 3,Phospholipid transporter ABCB1 |
| 2 | B, D (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | C, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F (A) | (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione | non-polymer | 494.6 | 1 | Chemie (JIZ) | |||
| 5 | G, H (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) | |||
| 6 | I (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 1 - 1271 (UniProt: P21447)
| PDB | External Database | Details |
|---|---|---|
| Gln 83 | Asn 83 | engineered mutation |
| Gln 87 | Asn 87 | engineered mutation |
| Gln 90 | Asn 90 | engineered mutation |
| Ala 133 | Cys 133 | engineered mutation |
| Gly 427 | Cys 427 | engineered mutation |
| Ala 713 | Cys 713 | engineered mutation |
| Ala 952 | Cys 952 | engineered mutation |
| Cys 971 | Leu 971 | engineered mutation |
| Gly 1070 | Cys 1070 | engineered mutation |
| Arg 1121 | Cys 1121 | engineered mutation |
| Val 1223 | Cys 1223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 140198.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2531.1 | |
| All* | Total formula weight | 142730.0 |
