7ZK6
ABCB1 L335C mutant (mABCB1) in the outward facing state bound to 2 molecules of AAC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ATP-dependent translocase ABCB1 | polymer | 1328 | 146063.9 | 1 | UniProt (P21447) Pfam (PF00664) Pfam (PF00005) | Mus musculus (house mouse) | ATP-binding cassette sub-family B member 1A,MDR1A,Multidrug resistance protein 1A,Multidrug resistance protein 3,P-glycoprotein 3,Phospholipid transporter ABCB1 |
| 2 | B, D (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | C, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 4 | F (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (60078761) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (73440805) PubChem (137392566) PubChem (137496323) PubChem (65082) PubChem (363416) PubChem (155804219) PubChem (99567469) PubChem (500055) PubChem (169132514) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (13301926) PubChem (13301927) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 5 | G (A) | (4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione | non-polymer | 692.8 | 1 | Chemie (JJI) PubChem (168007498) | |||
| 6 | H (A) | (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione | non-polymer | 494.6 | 1 | Chemie (JIZ) PubChem (168007496) | |||
| 7 | I (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 1 - 1276 (UniProt: P21447)
| PDB | External Database | Details |
|---|---|---|
| Gln 83 | Asn 83 | engineered mutation |
| Gln 87 | Asn 87 | engineered mutation |
| Gln 90 | Asn 90 | engineered mutation |
| Ala 133 | Cys 133 | engineered mutation |
| Cys 335 | Leu 335 | engineered mutation |
| Gly 427 | Cys 427 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
| Thr 669 | Cys 669 | engineered mutation |
| Ala 713 | Cys 713 | engineered mutation |
| Ala 952 | Cys 952 | engineered mutation |
| Gly 1070 | Cys 1070 | engineered mutation |
| Arg 1121 | Cys 1121 | engineered mutation |
| Val 1223 | Cys 1223 | engineered mutation |
| Leu 1277 | - | expression tag |
| Glu 1278 | - | expression tag |
| Glu 1279 | - | expression tag |
| Asn 1280 | - | expression tag |
| Leu 1281 | - | expression tag |
| Tyr 1282 | - | expression tag |
| Phe 1283 | - | expression tag |
| Gln 1284 | - | expression tag |
| Gly 1285 | - | expression tag |
| Gly 1286 | - | expression tag |
| Gly 1287 | - | expression tag |
| Ala 1288 | - | expression tag |
| Ser 1289 | - | expression tag |
| Gly 1290 | - | expression tag |
| Gly 1291 | - | expression tag |
| Ser 1292 | - | expression tag |
| Trp 1293 | - | expression tag |
| Ser 1294 | - | expression tag |
| His 1295 | - | expression tag |
| Pro 1296 | - | expression tag |
| Gln 1297 | - | expression tag |
| Phe 1298 | - | expression tag |
| Glu 1299 | - | expression tag |
| Lys 1300 | - | expression tag |
| Ala 1301 | - | expression tag |
| Ala 1302 | - | expression tag |
| Ala 1303 | - | expression tag |
| Gly 1304 | - | expression tag |
| Gly 1305 | - | expression tag |
| Gly 1306 | - | expression tag |
| Ser 1307 | - | expression tag |
| Gly 1308 | - | expression tag |
| Gly 1309 | - | expression tag |
| Gly 1310 | - | expression tag |
| Ser 1311 | - | expression tag |
| Trp 1312 | - | expression tag |
| Ser 1313 | - | expression tag |
| His 1314 | - | expression tag |
| Pro 1315 | - | expression tag |
| Gln 1316 | - | expression tag |
| Phe 1317 | - | expression tag |
| Glu 1318 | - | expression tag |
| Lys 1319 | - | expression tag |
| Gly 1320 | - | expression tag |
| Ser 1321 | - | expression tag |
| Gly 1322 | - | expression tag |
| His 1323 | - | expression tag |
| His 1324 | - | expression tag |
| His 1325 | - | expression tag |
| His 1326 | - | expression tag |
| His 1327 | - | expression tag |
| His 1328 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 146063.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2737.1 | |
| All* | Total formula weight | 148801.0 |
