7ZJF

R399E, a mutated form of GDF5, for disease modification of osteoarthritis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Growth/differentiation factor 5	polymer	120	13570.6	2	UniProt (P43026) Pfam (PF00019)	Homo sapiens (human)	GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LAP-4,LPS-associated protein 4,Radotermin
2	C, D (A, B)	water	water		18.0	306	Chemie (HOH)

Sequence modifications

A, B: 382 - 501 (UniProt: P43026)

PDB	External Database	Details
Glu 399	Arg 399	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27141.1
All*	Total formula weight	27141.1

*Water molecules are not included.