7ZF4

SARS-CoV-2 Omicron RBD in complex with Omi-9 Fab and nanobody F2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (F)	Nanobody F2	polymer	132	14962.6	1		Lama glama (llama)
2	B (H)	Omi-9 heavy chain	polymer	227	24128.0	1		Homo sapiens (human)
3	C (L)	Omi-9 light chain	polymer	217	23199.6	1		Homo sapiens (human)
4	D (E)	Spike protein S1	polymer	202	23157.2	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2 Omicron Spike protein

Sequence modifications

E: 333 - 526 (UniProt: P0DTC2)

PDB	External Database	Details
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Asp 339	Gly 339	variant
Leu 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Ser 446	Gly 446	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Arg 493	Gln 493	variant
Ser 496	Gly 496	variant
Arg 498	Gln 498	conflict
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
Lys 527	-	expression tag
Lys 528	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	85447.3
All*	Total formula weight	85447.3

*Water molecules are not included.