7ZD6
Complex I from Ovis aries, at pH7.4, Open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13106.5 | 1 | UniProt (O78753) Pfam (PF00507) | Ovis aries (sheep) | NADH dehydrogenase subunit 3 |
| 2 | B (H) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35884.9 | 1 | UniProt (O78747) Pfam (PF00146) | Ovis aries (sheep) | NADH dehydrogenase subunit 1 |
| 3 | C (J) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19126.6 | 1 | UniProt (O78757) Pfam (PF00499) | Ovis aries (sheep) | NADH dehydrogenase subunit 6 |
| 4 | D (K) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10868.2 | 1 | UniProt (O78754) Pfam (PF00420) | Ovis aries (sheep) | NADH dehydrogenase subunit 4L |
| 5 | E (L) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68438.9 | 1 | UniProt (O78756) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Ovis aries (sheep) | NADH dehydrogenase subunit 5 |
| 6 | F (M) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 52086.7 | 1 | UniProt (O78755) Pfam (PF01059) Pfam (PF00361) | Ovis aries (sheep) | NADH dehydrogenase subunit 4 |
| 7 | G (N) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39149.8 | 1 | UniProt (O78748) Pfam (PF00361) Pfam (PF06444) | Ovis aries (sheep) | NADH dehydrogenase subunit 2 |
| 8 | H (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 140 | 14652.8 | 1 | UniProt (A0A6P3E4K7) Pfam (PF02466) UniProt (by SIFTS) (A0A8N7XJ91) | Ovis aries (sheep) | Complex I-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7 |
| 9 | I (W) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 139 | 16317.0 | 1 | UniProt (A0A6P3E6Y9) Pfam (PF09781) UniProt (by SIFTS) (A0A8N7XJ68) | Ovis aries (sheep) | Complex I-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 10 | J, SA (X, j) | Acyl carrier protein | polymer | 157 | 17608.2 | 2 | UniProt (W5NQT7) Pfam (PF00550) | Ovis aries (sheep) | |
| 11 | K (Y) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 171 | 20008.0 | 1 | UniProt (A0A6P3EAP5) Pfam (PF06747) UniProt (by SIFTS) (A0A8N7XJG2) | Ovis aries (sheep) | |
| 12 | L (Z) | Complex I-PDSW | polymer | 171 | 20526.4 | 1 | UniProt (A0A6P3EI17) Pfam (PF10249) | Ovis aries (sheep) | |
| 13 | M (k) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 320 | 36883.7 | 1 | UniProt (W5QBF5) Pfam (PF01712) UniProt (by SIFTS) (A0A8N7XJK5) | Ovis aries (sheep) | |
| 14 | N (l) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 105 | 12474.4 | 1 | UniProt (A0A836D7R1) Pfam (PF10200) | Ovis aries (sheep) | Complex I-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 15 | O (m) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 80 | 8869.3 | 1 | UniProt (W5NYM7) Pfam (PF14987) UniProt (by SIFTS) (A0A836A4Q3) | Ovis aries (sheep) | Complex I-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 16 | P (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 79 | 8958.2 | 1 | UniProt (A0A6P3E8V0) Pfam (PF08122) UniProt (by SIFTS) (A0A6P7DQB1) | Ovis aries (sheep) | Complex I-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 17 | Q (o) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14231.4 | 1 | UniProt (W5P9Q8) Pfam (PF06374) | Ovis aries (sheep) | |
| 18 | R (p) | NADH:ubiquinone oxidoreductase subunit B4 | polymer | 128 | 14976.0 | 1 | UniProt (W5QF73) Pfam (PF07225) | Ovis aries (sheep) | |
| 19 | S (q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16766.5 | 1 | UniProt (A0A6P3E975) Pfam (PF06212) | Ovis aries (sheep) | |
| 20 | T (r) | Mitochondrial complex I, B17 subunit | polymer | 128 | 15565.1 | 1 | UniProt (W5PZE3) Pfam (PF09782) | Ovis aries (sheep) | |
| 21 | U (s) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 122 | 14963.1 | 1 | UniProt (W5P5V3) Pfam (PF05676) UniProt (by SIFTS) (A0A8N7XJH2) | Ovis aries (sheep) | Complex I-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 22 | V (t) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 177 | 21517.5 | 1 | UniProt (W5PGA3) Pfam (PF05347) UniProt (by SIFTS) (A0A6P3E749) | Ovis aries (sheep) | Complex I-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 23 | W (u) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 65 | 7898.8 | 1 | UniProt (A0A6P3EC72) Pfam (PF14813) UniProt (by SIFTS) (A0A8N7XJB4) | Ovis aries (sheep) | Complex I-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 24 | X (v) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 155 | 18521.8 | 1 | UniProt (W5Q1B0) Pfam (PF05821) | Ovis aries (sheep) | Complex I-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 25 | Y (w) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 101 | 11998.4 | 1 | UniProt (W5PWF1) Pfam (PF10183) UniProt (by SIFTS) (A0A836CQA7) | Ovis aries (sheep) | Complex I-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 26 | Z (x) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 49 | 5808.6 | 1 | UniProt (A0A6P3EDV0) Pfam (PF15088) | Ovis aries (sheep) | Complex I-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 27 | AA (y) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 50 | 6146.1 | 1 | UniProt (A0A7M4DUG1) Pfam (PF08040) | Ovis aries (sheep) | Complex I-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 28 | BA (z) | Complex I-MWFE | polymer | 70 | 8211.5 | 1 | UniProt (A0A7M4DUG2) Pfam (PF15879) UniProt (by SIFTS) (A0A6P9FRJ5) | Ovis aries (sheep) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1,NADH-ubiquinone oxidoreductase MWFE subunit |
| 29 | CA (1) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 430 | 47186.7 | 1 | UniProt (W5PUX0) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Ovis aries (sheep) | |
| 30 | DA (2) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 213 | 23598.2 | 1 | UniProt (W5NRY1) Pfam (PF01257) | Ovis aries (sheep) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 31 | EA (3) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 688 | 75520.5 | 1 | UniProt (W5QB34) Pfam (PF09326) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) UniProt (by SIFTS) (A0A9J4RF63) | Ovis aries (sheep) | |
| 32 | FA (4) | Complex I-49kD | polymer | 463 | 52661.5 | 1 | UniProt (A0A7M4DUF9) Pfam (PF00346) UniProt (by SIFTS) (A0A6P3DZ89) | Ovis aries (sheep) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2,mitochondrial,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 33 | GA (5) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 208 | 24381.5 | 1 | UniProt (W5PB27) Pfam (PF00329) | Ovis aries (sheep) | Complex I-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 34 | HA (6) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 156 | 17861.0 | 1 | UniProt (A0A6P7E4I4) Pfam (PF01058) UniProt (by SIFTS) (A0A6P7E5N1) | Ovis aries (sheep) | Complex I-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 35 | IA (9) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20219.9 | 1 | UniProt (A0A6P3TFB2) Pfam (PF12838) | Ovis aries (sheep) | Complex I-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit |
| 36 | JA (a) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 44 | 5263.8 | 1 | UniProt (A0A7M4DUF6) Pfam (PF15880) UniProt (by SIFTS) (A0A6P3E7B5) | Ovis aries (sheep) | Complex I-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 37 | KA (b) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 95 | 10513.6 | 1 | UniProt (A0A6P7EX23) Pfam (PF10276) | Ovis aries (sheep) | |
| 38 | LA (c) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 126 | 14559.5 | 1 | UniProt (W5PE07) Pfam (PF04800) | Ovis aries (sheep) | Complex I-18 kDa,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 39 | MA (d) | NADH:ubiquinone oxidoreductase subunit A9 | polymer | 380 | 43025.6 | 1 | UniProt (W5PI58) Pfam (PF01370) UniProt (by SIFTS) (A0A6P3E3I5) | Ovis aries (sheep) | |
| 40 | NA (e) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 86 | 9841.3 | 1 | UniProt (A0A6P3E5Z9) Pfam (PF05047) UniProt (by SIFTS) (A0A8N7XJ49) | Ovis aries (sheep) | |
| 41 | OA (f) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 113 | 13028.2 | 1 | UniProt (W5PNX7) Pfam (PF04716) UniProt (by SIFTS) (A0A836ABR5) | Ovis aries (sheep) | Complex I subunit B13,Complex I-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 42 | PA (g) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 114 | 13768.0 | 1 | UniProt (W5QC06) Pfam (PF05347) | Ovis aries (sheep) | Complex I-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 43 | QA (h) | Mitochondrial complex I, B14.5a subunit | polymer | 114 | 12701.6 | 1 | UniProt (W5P0I2) Pfam (PF07347) | Ovis aries (sheep) | |
| 44 | RA (i) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17115.5 | 1 | UniProt (A0A6P3CXE3) Pfam (PF05071) UniProt (by SIFTS) (A0A8N7XJ18) | Ovis aries (sheep) | |
| 45 | CB, DB, GB, TA, VA... (L, M, A, H) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 6 | Chemie (PC1) | |||
| 46 | AB, BB, EB, FB, HB... (K, L, M, N, V...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 14 | Chemie (3PE) | |||
| 47 | WA (H) | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione | non-polymer | 322.4 | 1 | Chemie (DCQ) | |||
| 48 | EC, NB (j, X) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) | |||
| 49 | OB (k) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) | |||
| 50 | PB (s) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 51 | AC, BC, QB, UB, VB... (9, 1, 3, 6) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 52 | RB (1) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 53 | SB (1) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 1 | Chemie (NAI) | |||
| 54 | TB, WB (2, 3) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 55 | XB (3) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 56 | CC (b) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 57 | DC (d) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 970419.0 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 21682.4 | |
| All* | Total formula weight | 992101.5 |
