7ZBZ
CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Cullin-1 | polymer | 776 | 89800.4 | 1 | UniProt (Q13616) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (human) | CUL-1 |
| 2 | B (D) | Cullin-associated NEDD8-dissociated protein 1 | polymer | 1238 | 137314.2 | 1 | UniProt (Q86VP6) Pfam (PF13513) Pfam (PF08623) | Homo sapiens (human) | Cullin-associated and neddylation-dissociated protein 1,TBP-interacting protein of 120 kDa A,TBP-interacting protein 120A,p120 CAND1 |
| 3 | C (R) | E3 ubiquitin-protein ligase RBX1 | polymer | 106 | 12089.7 | 1 | UniProt (I2CVJ6) Pfam (PF12678) UniProt (by SIFTS) (P62877) | Homo sapiens (human) | Ring-box 1 |
| 4 | D (S) | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 5 | E (F) | S-phase kinase-associated protein 2 | polymer | 426 | 47961.9 | 1 | UniProt (Q13309) Pfam (PF12937) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2 |
| 6 | F, G, H (R) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
D: 1 - 1230 (UniProt: Q86VP6)
R: 5 - 108 (UniProt: I2CVJ6)
F: 1 - 424 (UniProt: Q13309)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Val 952 | Ala 952 | variant |
| Gly 1072 | Lys 1072 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 305846.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 306042.3 |
