7ZA2

GPC3-Unc5D octamer structure and role in cell migration

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glypican-3	polymer	464	53323.6	4	UniProt (Q8CFZ4) Pfam (PF01153) In PDB	Mus musculus (house mouse)
2	E, F, G, H	Netrin receptor UNC5D	polymer	268	30258.0	4	UniProt (F1LW30) Pfam (PF07679) Pfam (PF00090) In PDB	Rattus norvegicus (Norway rat)	Protein unc-5 homolog D
3	I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	A, B, C, D, E...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	14	Chemie (NAG)
5	E, F, G	alpha-D-mannopyranose	non-polymer		180.2	3	Chemie (MAN)

Sequence modifications

A, B, C, D: 31 - 482 (UniProt: Q8CFZ4)

PDB	External Database	Details
Glu 28	-	expression tag
Thr 29	-	expression tag
Gly 30	-	expression tag
Gly 483	-	expression tag
Thr 484	-	expression tag
Lys 485	-	expression tag
His 486	-	expression tag
His 487	-	expression tag
His 488	-	expression tag
His 489	-	expression tag
His 490	-	expression tag
His 491	-	expression tag

E, F, G, H: 46 - 307 (UniProt: F1LW30)

PDB	External Database	Details
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	334326.3
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	17
	Total formula weight	3637.4
All*	Total formula weight	338388.1

*Water molecules are not included.