7Z6V
CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11 nanobody complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein,Fibritin | polymer | 1260 | 139877.9 | 3 | UniProt (P0DTC2) UniProt (P10104) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein,Collar protein,Whisker antigen control protein |
| 2 | D, E, F (X, Y, Z) | Nanobody H11 | polymer | 134 | 14996.7 | 3 | Lama glama | ||
| 3 | G, H, I, J, K... (D, E, F, G, H...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 19 | In PDB GlyTouCan (G42666HT) | |||
| 4 | AA, AB, BA, CA, DA... (A, C, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 28 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 1208 (UniProt: P0DTC2)
A, B, C: 1211 - 1238 (UniProt: P10104)
| PDB | External Database | Details |
|---|---|---|
| Gly 682 | Arg 682 | engineered mutation |
| Ser 683 | Arg 683 | engineered mutation |
| Ser 685 | Arg 685 | engineered mutation |
| Pro 986 | Lys 986 | engineered mutation |
| Pro 987 | Val 987 | engineered mutation |
| Gly 1209 | - | linker |
| Ser 1210 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 1232 | Phe 479 | conflict |
| Leu 1239 | - | expression tag |
| Leu 1240 | - | expression tag |
| Asn 1241 | - | expression tag |
| Asp 1242 | - | expression tag |
| Ile 1243 | - | expression tag |
| Phe 1244 | - | expression tag |
| Glu 1245 | - | expression tag |
| Ala 1246 | - | expression tag |
| Gln 1247 | - | expression tag |
| Lys 1248 | - | expression tag |
| Ile 1249 | - | expression tag |
| Glu 1250 | - | expression tag |
| Trp 1251 | - | expression tag |
| His 1252 | - | expression tag |
| Glu 1253 | - | expression tag |
| Lys 1254 | - | expression tag |
| His 1255 | - | expression tag |
| His 1256 | - | expression tag |
| His 1257 | - | expression tag |
| His 1258 | - | expression tag |
| His 1259 | - | expression tag |
| His 1260 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 464624.0 | |
| Branched | Number of molecules | 19 |
| Total formula weight | 8063.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 6193.8 | |
| All* | Total formula weight | 478881.4 |
