7Z6C
Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 366 | 39725.3 | 1 | UniProt (Q02127) Pfam (PF01180) In PDB | Homo sapiens (human) | DHOdehase,Dihydroorotate oxidase |
| 2 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 3 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 4 | A | ~{N}-(5-methyl-4-phenoxy-2-propan-2-yl-phenyl)-2-oxidanyl-pyrazolo[1,5-a]pyridine-3-carboxamide | non-polymer | 401.5 | 1 | Chemie (IEQ) | |||
| 5 | A | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 6 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 7 | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39725.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1355.3 | |
| All* | Total formula weight | 41080.6 |
