7Z5X
ROS1 with AstraZeneca ligand 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase ROS | polymer | 331 | 37651.0 | 2 | UniProt (P08922) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-Ros,Proto-oncogene c-Ros-1,Receptor tyrosine kinase c-ros oncogene 1,c-Ros receptor tyrosine kinase |
| 2 | C, D (A, B) | (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol | non-polymer | 472.5 | 2 | Chemie (AWJ) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A, B: 1930 - 2256 (UniProt: P08922)
| PDB | External Database | Details |
|---|---|---|
| Gly 1928 | - | expression tag |
| Ser 1929 | - | expression tag |
| Leu 2257 | - | expression tag |
| Glu 2258 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75301.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 945.1 | |
| All* | Total formula weight | 76247.0 |
