7Z5W
ROS1 with AstraZeneca ligand 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase ROS | polymer | 331 | 37651.0 | 2 | UniProt (P08922) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-Ros,Proto-oncogene c-Ros-1,Receptor tyrosine kinase c-ros oncogene 1,c-Ros receptor tyrosine kinase |
2 | A, B | ~{N}-[6-methyl-2-[(2~{S})-2-[3-(3-methylpyrazin-2-yl)-1,2-oxazol-5-yl]pyrrolidin-1-yl]pyrimidin-4-yl]-1,3-thiazol-2-amine | non-polymer | 420.5 | 2 | Chemie (IDW) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A, B: 1930 - 2256 (UniProt: P08922)
PDB | External Database | Details |
---|---|---|
Gly 1928 | - | expression tag |
Ser 1929 | - | expression tag |
Leu 2257 | - | expression tag |
Glu 2258 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75301.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1033.1 | |
All* | Total formula weight | 76335.0 |