7Z5U
Crystal structure of the peptidase domain of collagenase G from Clostridium histolyticum in complex with a hydroxamate-based inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Collagenase ColG | polymer | 415 | 47885.9 | 1 | UniProt (Q9X721) Pfam (PF01752) Pfam (PF18496) In PDB | Hathewaya histolytica | Class I collagenase,Gelatinase ColG,Microbial collagenase |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | (2~{R})-~{N}-[2-[4-[(2-acetamidophenoxy)methyl]-1,2,3-triazol-1-yl]ethyl]-2-(2-methylpropyl)-~{N}'-oxidanyl-propanediamide | non-polymer | 432.5 | 1 | Chemie (IFW) | |||
4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
5 | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A: 398 - 790 (UniProt: Q9X721)
PDB | External Database | Details |
---|---|---|
Met 376 | - | initiating methionine |
Gly 377 | - | expression tag |
Ser 378 | - | expression tag |
Ser 379 | - | expression tag |
His 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
Ser 386 | - | expression tag |
Ser 387 | - | expression tag |
Gly 388 | - | expression tag |
Glu 389 | - | expression tag |
Asn 390 | - | expression tag |
Leu 391 | - | expression tag |
Tyr 392 | - | expression tag |
Phe 393 | - | expression tag |
Gln 394 | - | expression tag |
Gly 395 | - | expression tag |
Gly 396 | - | expression tag |
Thr 397 | - | expression tag |
Leu 575 | Ser 575 | engineered mutation |
Val 665 | Ala 665 | engineered mutation |
Gly 790 | Ala 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 47885.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 538.0 | |
All* | Total formula weight | 48423.8 |