7Z5N
Crystal structure of DYRK1A in complex with CX-4945
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 370 | 43180.6 | 8 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,MNBH,hMNB |
| 2 | CB, GA, I, JB, OA... (G, C, A, H, D...) | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | non-polymer | 349.8 | 8 | Chemie (3NG) | |||
| 3 | AB, DB, EB, HA, IA... (F, G, C, A, H...) | SULFATE ION | non-polymer | 96.1 | 22 | Chemie (SO4) | |||
| 4 | AA, BA, KA, LB, O... (B, C, H, A, D...) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 8 | Chemie (PG4) | |||
| 5 | FB, GB, Q, XA (G, A, E) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 6 | BB, CA, DA, EA, HB... (F, B, G, C, A...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 7 | FA, MB (B, H) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 8 | NB, OB, PB, QB, RB... (A, B, C, D, E...) | water | water | 18.0 | 206 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 126 - 489 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| His 490 | - | expression tag |
| His 491 | - | expression tag |
| His 492 | - | expression tag |
| His 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 345444.6 | |
| Non-Polymers* | Number of molecules | 57 |
| Total formula weight | 7997.1 | |
| All* | Total formula weight | 353441.7 |
