7Z3Q

Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (A, C, E)	Leptin	polymer	171	18605.1	3	UniProt (P41159) Pfam (PF02024)	Homo sapiens (human)	Obese protein,Obesity factor
2	B, D, F (B, D, F)	Leptin receptor	polymer	232	26116.6	3	UniProt (P48357) Pfam (PF18589)	Homo sapiens (human)	LEP-R,HuB219,OB receptor,OB-R
3	G, H (B, C)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, C, E: 22 - 167 (UniProt: P41159)

PDB	External Database	Details
Ala -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
Pro 4	-	expression tag
Gly 5	-	expression tag
Gly 6	-	expression tag
Pro 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
Glu 10	-	expression tag
Asn 11	-	expression tag
Leu 12	-	expression tag
Tyr 13	-	expression tag
Phe 14	-	expression tag
Gln 15	-	expression tag
Gly 16	-	expression tag
Gly 17	-	expression tag
Ser 18	-	expression tag
Thr 19	-	expression tag
Gly 20	-	expression tag
Gly 21	-	expression tag

B, D, F: 428 - 635 (UniProt: P48357)

PDB	External Database	Details
Ala 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag
His 410	-	expression tag
Pro 411	-	expression tag
Gly 412	-	expression tag
Gly 413	-	expression tag
Pro 414	-	expression tag
Gly 415	-	expression tag
Ser 416	-	expression tag
Glu 417	-	expression tag
Asn 418	-	expression tag
Leu 419	-	expression tag
Tyr 420	-	expression tag
Phe 421	-	expression tag
Gln 422	-	expression tag
Gly 423	-	expression tag
Gly 424	-	expression tag
Ser 425	-	expression tag
Ser 426	-	expression tag
Gly 427	-	expression tag
Gln 516	Asn 516	conflict
Ser 604	Cys 604	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	134165.1
All*	Total formula weight	134165.1

*Water molecules are not included.