7Z3Q
Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E | Leptin | polymer | 171 | 18605.1 | 3 | UniProt (P41159) Pfam (PF02024) In PDB | Homo sapiens (human) | Obese protein,Obesity factor |
| 2 | B, D, F | Leptin receptor | polymer | 232 | 26116.6 | 3 | UniProt (P48357) Pfam (PF18589) In PDB | Homo sapiens (human) | LEP-R,HuB219,OB receptor,OB-R |
| 3 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, C, E: 22 - 167 (UniProt: P41159)
B, D, F: 428 - 635 (UniProt: P48357)
| PDB | External Database | Details |
|---|---|---|
| Ala -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| His 2 | - | expression tag |
| His 3 | - | expression tag |
| Pro 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Gly 6 | - | expression tag |
| Pro 7 | - | expression tag |
| Gly 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Glu 10 | - | expression tag |
| Asn 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Tyr 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Gln 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Gly 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Thr 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Gly 21 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| Pro 411 | - | expression tag |
| Gly 412 | - | expression tag |
| Gly 413 | - | expression tag |
| Pro 414 | - | expression tag |
| Gly 415 | - | expression tag |
| Ser 416 | - | expression tag |
| Glu 417 | - | expression tag |
| Asn 418 | - | expression tag |
| Leu 419 | - | expression tag |
| Tyr 420 | - | expression tag |
| Phe 421 | - | expression tag |
| Gln 422 | - | expression tag |
| Gly 423 | - | expression tag |
| Gly 424 | - | expression tag |
| Ser 425 | - | expression tag |
| Ser 426 | - | expression tag |
| Gly 427 | - | expression tag |
| Gln 516 | Asn 516 | conflict |
| Ser 604 | Cys 604 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 134165.1 | |
| All* | Total formula weight | 134165.1 |
