7Z3Q
Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E | Leptin | polymer | 171 | 18605.1 | 3 | UniProt (P41159) Pfam (PF02024) In PDB | Homo sapiens (human) | Obese protein,Obesity factor |
2 | B, D, F | Leptin receptor | polymer | 232 | 26116.6 | 3 | UniProt (P48357) Pfam (PF18589) In PDB | Homo sapiens (human) | LEP-R,HuB219,OB receptor,OB-R |
3 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, C, E: 22 - 167 (UniProt: P41159)
B, D, F: 428 - 635 (UniProt: P48357)
PDB | External Database | Details |
---|---|---|
Ala -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
Pro 4 | - | expression tag |
Gly 5 | - | expression tag |
Gly 6 | - | expression tag |
Pro 7 | - | expression tag |
Gly 8 | - | expression tag |
Ser 9 | - | expression tag |
Glu 10 | - | expression tag |
Asn 11 | - | expression tag |
Leu 12 | - | expression tag |
Tyr 13 | - | expression tag |
Phe 14 | - | expression tag |
Gln 15 | - | expression tag |
Gly 16 | - | expression tag |
Gly 17 | - | expression tag |
Ser 18 | - | expression tag |
Thr 19 | - | expression tag |
Gly 20 | - | expression tag |
Gly 21 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 404 | - | expression tag |
His 405 | - | expression tag |
His 406 | - | expression tag |
His 407 | - | expression tag |
His 408 | - | expression tag |
His 409 | - | expression tag |
His 410 | - | expression tag |
Pro 411 | - | expression tag |
Gly 412 | - | expression tag |
Gly 413 | - | expression tag |
Pro 414 | - | expression tag |
Gly 415 | - | expression tag |
Ser 416 | - | expression tag |
Glu 417 | - | expression tag |
Asn 418 | - | expression tag |
Leu 419 | - | expression tag |
Tyr 420 | - | expression tag |
Phe 421 | - | expression tag |
Gln 422 | - | expression tag |
Gly 423 | - | expression tag |
Gly 424 | - | expression tag |
Ser 425 | - | expression tag |
Ser 426 | - | expression tag |
Gly 427 | - | expression tag |
Gln 516 | Asn 516 | conflict |
Ser 604 | Cys 604 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 134165.1 | |
All* | Total formula weight | 134165.1 |