7Z28
High-resolution crystal structure of ERAP1 with bound bestatin analogue inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Endoplasmic reticulum aminopeptidase 1 | polymer | 859 | 98405.3 | 1 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB | Homo sapiens (human) | ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| 2 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | A | methyl (2~{S})-2-[[(2~{S})-2-[[(2~{S},3~{R})-3-azanyl-2,7-bis(oxidanyl)heptanoyl]amino]-4-methyl-pentanoyl]amino]-3-(4-hydroxyphenyl)propanoate | non-polymer | 467.6 | 1 | Chemie (I88) | |||
| 6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 18 | Chemie (EDO) | |||
| 7 | A | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
| 8 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 9 | water | water | 18.0 | 882 | Chemie (HOH) |
Sequence modifications
A: 45 - 936 (UniProt: Q9NZ08)
| PDB | External Database | Details |
|---|---|---|
| - | Cys 486 | deletion |
| - | Pro 487 | deletion |
| - | Thr 488 | deletion |
| - | Asp 489 | deletion |
| - | Gly 490 | deletion |
| - | Val 491 | deletion |
| - | Lys 492 | deletion |
| - | Gly 493 | deletion |
| - | Met 494 | deletion |
| - | Asp 495 | deletion |
| - | Gly 496 | deletion |
| - | Phe 497 | deletion |
| - | Cys 498 | deletion |
| - | Ser 499 | deletion |
| - | Arg 500 | deletion |
| - | Ser 501 | deletion |
| - | Gln 502 | deletion |
| - | His 503 | deletion |
| - | Ser 504 | deletion |
| - | Ser 505 | deletion |
| - | Ser 506 | deletion |
| - | Ser 507 | deletion |
| - | Ser 508 | deletion |
| - | His 509 | deletion |
| - | Trp 510 | deletion |
| - | His 511 | deletion |
| - | Gln 512 | deletion |
| - | Glu 513 | deletion |
| Ser 487 | Gly 514 | conflict |
| Gly 515 | Val 515 | conflict |
| - | Ser 553 | deletion |
| - | Asp 554 | deletion |
| - | Gly 555 | deletion |
| - | Ala 556 | deletion |
| - | Pro 557 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 98405.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2155.7 | |
| All* | Total formula weight | 100985.4 |
