7Z0L

IL-27 signalling complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-6 receptor subunit beta	polymer	292	32914.0	1	UniProt (Q00560) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041)	Mus musculus (house mouse)	IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha
2	B (B)	Interleukin-27 subunit beta,Interleukin-27 subunit alpha	polymer	471	52475.3	1	UniProt (O35228) UniProt (Q8K3I6) Pfam (PF00041)	Mus musculus (house mouse)	IL-27 subunit beta,IL-27B,Epstein-Barr virus-induced gene 3 protein homolog,IL-27 subunit alpha,IL-27-A,IL27-A,p28
3	C (C)	Interleukin-27 receptor subunit alpha	polymer	230	25968.4	1	UniProt (O70394)	Mus musculus (house mouse)	IL-27 receptor subunit alpha,IL-27R subunit alpha,IL-27R-alpha,IL-27RA,Type I T-cell cytokine receptor,TCCR,WSX-1
4	D, E, F, G, H (E, F, G, H, I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
5	I, J (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

B: 19 - 228 (UniProt: O35228)

PDB	External Database	Details
Met -3	-	initiating methionine
Val -2	-	expression tag
Ser -1	-	expression tag
Ala 0	-	expression tag
Ile 1	-	expression tag
Val 2	-	expression tag
Leu 3	-	expression tag
Tyr 4	-	expression tag
Val 5	-	expression tag
Leu 6	-	expression tag
Leu 7	-	expression tag
Ala 8	-	expression tag
Ala 9	-	expression tag
Ala 10	-	expression tag
Ala 11	-	expression tag
His 12	-	expression tag
Ser 13	-	expression tag
Ala 14	-	expression tag
Phe 15	-	expression tag
Ala 16	-	expression tag
Gly 17	-	expression tag
Ser 18	-	expression tag
Arg 229	-	linker
Gly 230	-	linker
Gly 231	-	linker
Gly 232	-	linker
Gly 233	-	linker
Ser 234	-	linker
Gly 235	-	linker
Gly 236	-	linker
Gly 237	-	linker
Gly 238	-	linker
Ser 239	-	linker
Val 240	-	linker
Glu 241	-	linker
Ser 242	-	linker
Gly 243	-	linker
Glu 244	-	linker
Asn 245	-	linker
Leu 246	-	linker
Tyr 247	-	linker
Phe 248	-	linker
Gln 249	-	linker

B: 250 - 456 (UniProt: Q8K3I6)

PDB	External Database	Details
Ala 457	-	expression tag
Ala 458	-	expression tag
Ala 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag
His 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag

C: 28 - 224 (UniProt: O70394)

PDB	External Database	Details
Met 6	-	initiating methionine
Val 7	-	expression tag
Ser 8	-	expression tag
Ala 9	-	expression tag
Ile 10	-	expression tag
Val 11	-	expression tag
Leu 12	-	expression tag
Tyr 13	-	expression tag
Val 14	-	expression tag
Leu 15	-	expression tag
Leu 16	-	expression tag
Ala 17	-	expression tag
Ala 18	-	expression tag
Ala 19	-	expression tag
Ala 20	-	expression tag
His 21	-	expression tag
Ser 22	-	expression tag
Ala 23	-	expression tag
Phe 24	-	expression tag
Ala 25	-	expression tag
Gly 26	-	expression tag
Ser 27	-	expression tag
Ala 225	-	expression tag
Ala 226	-	expression tag
Ala 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag
His 233	-	expression tag
His 234	-	expression tag
His 235	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	111357.7
Branched	Number of molecules	5
	Total formula weight	2122.0
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	113922.1

*Water molecules are not included.