7YXN
Crystal structure of WT AncGR2-LBD bound to dexamethasone and SHP coregulator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Ancestral Glucocorticoid Receptor2 | polymer | 250 | 28835.5 | 2 | UniProt (A0A1X8XLE9) Pfam (PF00104) | unidentified | |
| 2 | C, D (R, S) | SHP NR Box 1 Peptide | polymer | 11 | 1204.4 | 2 | UniProt (Q15466) | Homo sapiens | Orphan nuclear receptor SHP,Small heterodimer partner,Nuclear receptor subfamily 0 group B member 2 |
| 3 | E, H (A, C) | DEXAMETHASONE | non-polymer | 392.5 | 2 | Chemie (DEX) | |||
| 4 | F, G, I, J (A, C) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 5 | K, L, M (A, C, S) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, C: 530 - 776 (UniProt: A0A1X8XLE9)
| PDB | External Database | Details |
|---|---|---|
| Gly 527 | - | expression tag |
| Glu 528 | - | expression tag |
| Phe 529 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60079.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 969.0 | |
| All* | Total formula weight | 61048.9 |
