7YXE

Crystal structure of YTHDF2 with compound ZA_143

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	YTH domain-containing family protein 2	polymer	167	19367.8	2	UniProt (Q9Y5A9) Pfam (PF04146) In PDB	Homo sapiens (human)	CLL-associated antigen KW-14,High-glucose-regulated protein 8,Renal carcinoma antigen NY-REN-2
2	A, B	~{N}-methyl-3-phenyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine	non-polymer		225.2	2	Chemie (I82)
3	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6		water	water		18.0	147	Chemie (HOH)

Sequence modifications

A, B: 408 - 552 (UniProt: Q9Y5A9)

PDB	External Database	Details
Met 386	-	initiating methionine
Gly 387	-	expression tag
Ser 388	-	expression tag
Ser 389	-	expression tag
Tyr 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
Ser 397	-	expression tag
Ser 398	-	expression tag
Gly 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag
His 406	-	expression tag
Met 407	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38735.7
Non-Polymers*	Number of molecules	8
	Total formula weight	949.8
All*	Total formula weight	39685.5

*Water molecules are not included.