7YXD
Crystal structure of WT AncGR2-LBD bound to dexamethasone and SHP coregulator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, D, H, L) | Ancestral Glucocorticoid Receptor2 | polymer | 248 | 28649.4 | 4 | UniProt (A0A1X8XLE9) Pfam (PF00104) | unidentified | |
| 2 | B, D, F, H (C, F, J, N) | SHP NR Box 1 Peptide | polymer | 12 | 1291.5 | 4 | UniProt (Q15466) | Homo sapiens (human) | Orphan nuclear receptor SHP,Small heterodimer partner,Nuclear receptor subfamily 0 group B member 2 |
| 3 | I, J, K, M (A, D, H, L) | DEXAMETHASONE | non-polymer | 392.5 | 4 | Chemie (DEX) | |||
| 4 | L (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | N, O, P, Q (A, D, H, L) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, D, H, L: 530 - 776 (UniProt: A0A1X8XLE9)
| PDB | External Database | Details |
|---|---|---|
| Phe 529 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 119763.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1592.8 | |
| All* | Total formula weight | 121356.4 |
