7YU3
Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7547.7 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (cattle) | G gamma-I |
| 4 | R | Lysophosphatidic acid receptor 1 | polymer | 379 | 42936.0 | 1 | UniProt (Q92633) Pfam (PF00001) In PDB | Homo sapiens (human) | LPA receptor 1,LPA-1,Lysophosphatidic acid receptor Edg-2 |
| 5 | S | scFv16 | polymer | 260 | 27720.8 | 1 | Mus musculus | ||
| 6 | R | [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate | non-polymer | 415.5 | 1 | Chemie (K6L) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
G: 1 - 67 (UniProt: P63212)
R: 2 - 364 (UniProt: Q92633)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Met 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Glu 365 | - | expression tag |
| Asn 366 | - | expression tag |
| Leu 367 | - | expression tag |
| Tyr 368 | - | expression tag |
| Phe 369 | - | expression tag |
| Gln 370 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 157363.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 415.5 | |
| All* | Total formula weight | 157779.3 |
