7YTX
Crystal structure of TLR8 in complex with its antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 8 | polymer | 811 | 92835.4 | 2 | UniProt (Q9NR97) Pfam (PF13855) | Homo sapiens (human) | |
| 2 | C (C) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 3 | D, G (D, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | E, H (E, I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G07617FP) | |||
| 5 | F (G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | I, S (A, B) | (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide | non-polymer | 383.4 | 2 | Chemie (JRI) | |||
| 7 | AA, BA, J, K, L... (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
A, B: 27 - 827 (UniProt: Q9NR97)
| PDB | External Database | Details |
|---|---|---|
| Arg 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Trp 26 | - | expression tag |
| Glu 828 | - | expression tag |
| Phe 829 | - | expression tag |
| Leu 830 | - | expression tag |
| Val 831 | - | expression tag |
| Pro 832 | - | expression tag |
| Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 185670.7 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 4978.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4748.6 | |
| All* | Total formula weight | 195397.8 |
