7YTP

TLR7 in complex with an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Toll-like receptor 7	polymer	975	111561.3	2	UniProt (B3Y653) Pfam (PF13855)	Macaca mulatta (Rhesus monkey)
2	C, D, E, F, G... (C, D, E, F, G...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	I, J, K, L, M... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)
4	N, T (A, B)	(2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide	non-polymer		383.4	2	Chemie (JRI)

Sequence modifications

A, B: 27 - 839 (UniProt: B3Y653)

PDB	External Database	Details
Met 5	-	initiating methionine
Lys 6	-	expression tag
Leu 7	-	expression tag
Cys 8	-	expression tag
Ile 9	-	expression tag
Leu 10	-	expression tag
Leu 11	-	expression tag
Ala 12	-	expression tag
Val 13	-	expression tag
Val 14	-	expression tag
Ala 15	-	expression tag
Phe 16	-	expression tag
Val 17	-	expression tag
Gly 18	-	expression tag
Leu 19	-	expression tag
Ser 20	-	expression tag
Leu 21	-	expression tag
Gly 22	-	expression tag
Arg 23	-	expression tag
Ser 24	-	expression tag
Pro 25	-	expression tag
Trp 26	-	expression tag
Gln 167	Asn 167	engineered mutation
Gln 389	Asn 389	engineered mutation
Leu 440	Ser 440	engineered mutation
Val 441	Glu 441	engineered mutation
Pro 442	Val 442	engineered mutation
Arg 443	Gly 443	engineered mutation
Gly 444	Phe 444	engineered mutation
Ser 445	Cys 445	engineered mutation
Gln 488	Asn 488	engineered mutation
Gln 799	Asn 799	engineered mutation

A, B: 840 - 979 (PDB: 7YTP)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	223122.5
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	12
	Total formula weight	2978.9
All*	Total formula weight	228647.9

*Water molecules are not included.