7YTP
TLR7 in complex with an inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Toll-like receptor 7 | polymer | 975 | 111561.3 | 2 | UniProt (B3Y653) Pfam (PF13855) In PDB | Macaca mulatta (Rhesus monkey) | |
2 | C, D, E, F, G... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
4 | A, B | (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide | non-polymer | 383.4 | 2 | Chemie (JRI) |
Sequence modifications
A, B: 27 - 839 (UniProt: B3Y653)
A, B: 840 - 979 (PDB: 7YTP)
PDB | External Database | Details |
---|---|---|
Met 5 | - | initiating methionine |
Lys 6 | - | expression tag |
Leu 7 | - | expression tag |
Cys 8 | - | expression tag |
Ile 9 | - | expression tag |
Leu 10 | - | expression tag |
Leu 11 | - | expression tag |
Ala 12 | - | expression tag |
Val 13 | - | expression tag |
Val 14 | - | expression tag |
Ala 15 | - | expression tag |
Phe 16 | - | expression tag |
Val 17 | - | expression tag |
Gly 18 | - | expression tag |
Leu 19 | - | expression tag |
Ser 20 | - | expression tag |
Leu 21 | - | expression tag |
Gly 22 | - | expression tag |
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Pro 25 | - | expression tag |
Trp 26 | - | expression tag |
Gln 167 | Asn 167 | engineered mutation |
Gln 389 | Asn 389 | engineered mutation |
Leu 440 | Ser 440 | engineered mutation |
Val 441 | Glu 441 | engineered mutation |
Pro 442 | Val 442 | engineered mutation |
Arg 443 | Gly 443 | engineered mutation |
Gly 444 | Phe 444 | engineered mutation |
Ser 445 | Cys 445 | engineered mutation |
Gln 488 | Asn 488 | engineered mutation |
Gln 799 | Asn 799 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 223122.5 | |
Branched | Number of molecules | 6 |
Total formula weight | 2546.4 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2978.9 | |
All* | Total formula weight | 228647.9 |