7YSU
Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Klotho | polymer | 942 | 108404.9 | 1 | UniProt (Q9UEF7) Pfam (PF00232) | Homo sapiens (human) | |
| 2 | B, C (C, E) | Fibroblast growth factor receptor 3 | polymer | 211 | 23358.4 | 2 | UniProt (P22607) Pfam (PF07679) Pfam (PF13927) | Homo sapiens (human) | FGFR-3 |
| 3 | D (B) | Fibroblast growth factor 23 | polymer | 179 | 20450.1 | 1 | UniProt (Q9GZV9) Pfam (PF00167) | Homo sapiens (human) | FGF-23,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor |
| 4 | E (F) | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid | branched | 2905.4 | 1 | In PDB | |||
| 5 | F (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | G (E) | COPPER (II) ION | non-polymer | 63.5 | 1 | Chemie (CU) |
Sequence modifications
B: 25 - 203 (UniProt: Q9GZV9)
| PDB | External Database | Details |
|---|---|---|
| Gln 176 | Arg 176 | variant |
| Gln 179 | Arg 179 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 175571.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 2905.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 129.0 | |
| All* | Total formula weight | 178606.2 |
