7YRD

histone methyltransferase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3.2	polymer	103	12046.1	2	UniProt (P84233) Pfam (PF00125) UniProt (by SIFTS) (Q71DI3) In PDB	Xenopus laevis (African clawed frog)
2	B, F	Histone H4	polymer	102	11265.2	2	UniProt (P62799) Pfam (PF15511) UniProt (by SIFTS) (P62805) In PDB	Xenopus laevis (African clawed frog)
3	I, J	DNA (146-MER)	polymer	146	45054.8	2		Homo sapiens
4	C, G	Histone H2A.Z	polymer	113	12091.1	2	UniProt (P0C0S5) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (human)	H2A/z
5	D, H	Histone H2B 1.1	polymer	95	10607.2	2	UniProt (P02281) Pfam (PF00125) UniProt (by SIFTS) (P06899) In PDB	Xenopus laevis (African clawed frog)	H2B1.1
6	K	[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B	polymer	279	32214.8	1	UniProt (B7WNX0) Pfam (PF00856) UniProt (by SIFTS) (Q4FZB7) In PDB	Homo sapiens (human)	[histone H4]-lysine20 N-methyltransferase KMT5B
7	K	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
8	K	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)

Sequence modifications

A, E: 33 - 135 (UniProt: P84233)

PDB	External Database	Details
Glu 34	Gly 35	engineered mutation
Ala 102	Gly 103	engineered mutation

B, F: 1 - 102 (UniProt: P62799)

PDB	External Database	Details
Ecx 20	Lys 21	modified residue

D, H: 31 - 125 (UniProt: P02281)

PDB	External Database	Details
Thr 32	Ser 33	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	214343.8
Non-Polymers*	Number of molecules	2
	Total formula weight	463.8
All*	Total formula weight	214807.6

*Water molecules are not included.