7YOW

Crystal structure of SARS-CoV-2 omicron variant spike receptor-binding domain (RBD) in complex with NCV2SG48 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (L, A)	Fab Light chain	polymer	215	23276.9	2		Homo sapiens
2	B, E (H, B)	Fab Heavy chain	polymer	230	24611.6	2		Homo sapiens
3	C, F (R, C)	Spike protein S1	polymer	224	25553.9	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
4	G, H, I, J, K... (L, H, R, A, B...)	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)

Sequence modifications

R, C: 321 - 536 (UniProt: P0DTC2)

PDB	External Database	Details
Asp 339	Gly 339	variant
Leu 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Ser 446	Gly 446	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Arg 493	Gln 493	variant
Ser 496	Gly 496	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
Thr 537	-	expression tag
Gly 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
His 541	-	expression tag
His 542	-	expression tag
His 543	-	expression tag
His 544	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	146884.7
Non-Polymers*	Number of molecules	12
	Total formula weight	1152.8
All*	Total formula weight	148037.5

*Water molecules are not included.