7YO4
Cryo-EM structure of RCK1-RCK2 mutated human Slo1-LRRC26 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Calcium-activated potassium channel subunit alpha-1 | polymer | 1056 | 118877.0 | 4 | UniProt (A0A1W2PRB0) Pfam (PF00520) Pfam (PF22614) Pfam (PF03493) Pfam (PF21014) UniProt (by SIFTS) (Q12791) | Homo sapiens (human) | BK channel,BKCA alpha,Calcium-activated potassium channel,subfamily M subunit alpha-1,K(VCA)alpha,KCa1.1,Maxi K channel,Slo-alpha,Slo1,Slowpoke homolog |
| 2 | B, D, F, H (B, D, F, H) | Leucine-rich repeat-containing protein 26 | polymer | 334 | 34893.6 | 4 | UniProt (Q2I0M4) Pfam (PF13855) | Homo sapiens (human) | BK channel auxiliary gamma subunit LRRC26,Cytokeratin-associated protein in cancer |
Sequence modifications
A, C, E, G: 1 - 1056 (UniProt: A0A1W2PRB0)
| PDB | External Database | Details |
|---|---|---|
| Ala 362 | Asp 427 | engineered mutation |
| Ala 367 | Asp 432 | engineered mutation |
| - | Arg 643 | deletion |
| - | Ser 644 | deletion |
| - | Arg 645 | deletion |
| - | Lys 646 | deletion |
| Asn 894 | Asp 963 | engineered mutation |
| Asn 895 | Asp 964 | engineered mutation |
| Asn 896 | Asp 965 | engineered mutation |
| Asn 897 | Asp 966 | engineered mutation |
| Asn 898 | Asp 967 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 615082.5 | |
| All* | Total formula weight | 615082.5 |
