7YO1
Cryo-EM structure of RCK1 mutated human Slo1-LRRC26 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G | Calcium-activated potassium channel subunit alpha-1 | polymer | 1060 | 119370.5 | 4 | UniProt (A0A1W2PRB0) Pfam (PF00520) Pfam (PF07885) Pfam (PF22614) Pfam (PF03493) Pfam (PF21014) UniProt (by SIFTS) (Q12791) In PDB | Homo sapiens (human) | Calcium-activated potassium channel,subfamily M subunit alpha-1,K(VCA)alpha,KCa1.1 |
| 2 | B, D, F, H | Leucine-rich repeat-containing protein 26 | polymer | 334 | 34893.6 | 4 | UniProt (Q2I0M4) Pfam (PF13855) In PDB | Homo sapiens (human) | BK channel auxiliary gamma subunit LRRC26,Cytokeratin-associated protein in cancer |
| 3 | A, C, E, G | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | A, C, E, G | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) |
Sequence modifications
A, C, E, G: 1 - 1056 (UniProt: A0A1W2PRB0)
| PDB | External Database | Details |
|---|---|---|
| Ala 362 | Asp 427 | engineered mutation |
| Ala 367 | Asp 432 | engineered mutation |
| Ser 577 | Lys 646 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 617056.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 417.8 | |
| All* | Total formula weight | 617474.3 |
