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7YJC

Crystal structure of Human HPSE1 in complex with inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Heparanase 50 kDa subunitpolymer38643464.11UniProt (Q9Y251)
Pfam (PF03662)
Homo sapiens (human)
2B
(B)
Heparanase 8 kDa subunitpolymer748273.51UniProt (Q9Y251)Homo sapiens (human)
3C
(A)
(5~{S},6~{R},7~{S},8~{S})-6,7,8-tris(oxidanyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acidnon-polymer214.21Chemie (IVO)
4D, E
(A, B)
waterwater18.053Chemie (HOH)
Sequence modifications
A: 158 - 543 (UniProt: Q9Y251)
PDBExternal DatabaseDetails
Arg 307Lys 307engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight51737.6
Non-Polymers*Number of molecules1
Total formula weight214.2
All*Total formula weight51951.8
*Water molecules are not included.

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PDB entries from 2025-10-15

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