7YIW
The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, D, C, B, G...) | Alkaline phosphatase, tissue-nonspecific isozyme | polymer | 503 | 55459.4 | 8 | UniProt (P05186) Pfam (PF00245) | Homo sapiens (human) | AP-TNAP,TNS-ALP,TNSALP,Alkaline phosphatase liver/bone/kidney isozyme,Phosphoamidase,Phosphocreatine phosphatase |
| 2 | I, J, K, L, M... (K, N, U, X, e...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 16 | In PDB GlyTouCan (G42666HT) | |||
| 3 | CB, DB, EA, FA, IB... (H, D, F, C, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 16 | Chemie (NAG) | |||
| 4 | AA, EB, GA, KB, MA... (A, H, D, F, C...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 5 | BA, BB, DA, FB, HA... (A, G, H, D, F...) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) | |||
| 6 | AB, CA, GB, IA, MB... (G, A, H, D, F...) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 7 | UB, VB, WB, XB, YB (D, B, G, H, F) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, D, C, B, G, H, F, E: 18 - 500 (UniProt: P05186)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Lys 0 | - | expression tag |
| Thr 1 | - | expression tag |
| Ile 2 | - | expression tag |
| Ile 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Tyr 7 | - | expression tag |
| Ile 8 | - | expression tag |
| Phe 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Leu 11 | - | expression tag |
| Val 12 | - | expression tag |
| Phe 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Arg 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Ala 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 443675.2 | |
| Branched | Number of molecules | 16 |
| Total formula weight | 6790.4 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 5100.9 | |
| All* | Total formula weight | 455566.5 |
