7YIU
Cryo-EM structure of the C6-ceramide-bound SPT-ORMDL3 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Serine palmitoyltransferase 2 | polymer | 562 | 63004.2 | 1 | UniProt (O15270) Pfam (PF00155) In PDB | Homo sapiens (human) | Serine-palmitoyl-CoA transferase 2,SPT 2 |
2 | E | Serine palmitoyltransferase 1 | polymer | 50 | 5899.0 | 1 | UniProt (O15269) In PDB | Homo sapiens (human) | Long chain base biosynthesis protein 1,LCB 1,Serine-palmitoyl-CoA transferase 1,SPT 1,SPT1 |
3 | D | ORM1-like protein 3 | polymer | 153 | 17512.6 | 1 | UniProt (Q8N138) Pfam (PF04061) In PDB | Homo sapiens (human) | |
4 | C | Serine palmitoyltransferase small subunit A | polymer | 92 | 10742.4 | 1 | UniProt (Q969W0) Pfam (PF11779) In PDB | Homo sapiens (human) | Small subunit of serine palmitoyltransferase A,ssSPTa |
5 | A | Serine palmitoyltransferase 1 | polymer | 423 | 46925.8 | 1 | UniProt (O15269) Pfam (PF00155) In PDB | Homo sapiens (human) | Long chain base biosynthesis protein 1,LCB 1,Serine-palmitoyl-CoA transferase 1,SPT 1,SPT1 |
6 | B | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) | |||
7 | D | N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)HEXANAMIDE | non-polymer | 397.6 | 1 | Chemie (6CM) | |||
8 | D | HEXADECANE | non-polymer | 226.4 | 2 | Chemie (R16) |
Sequence modifications
C: 1 - 71 (UniProt: Q969W0)
PDB | External Database | Details |
---|---|---|
Met -20 | - | initiating methionine |
Ala -19 | - | expression tag |
Asp -18 | - | expression tag |
Tyr -17 | - | expression tag |
Lys -16 | - | expression tag |
Asp -15 | - | expression tag |
Asp -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Lys -11 | - | expression tag |
Ser -10 | - | expression tag |
Gly -9 | - | expression tag |
Pro -8 | - | expression tag |
Asp -7 | - | expression tag |
Glu -6 | - | expression tag |
Val -5 | - | expression tag |
Asp -4 | - | expression tag |
Ala -3 | - | expression tag |
Ser -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 144084.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1097.7 | |
All* | Total formula weight | 145181.6 |