7YIT
Molecular mechanism of biased signaling at the kappa opioid receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kappa-type opioid receptor | polymer | 305 | 34687.3 | 1 | UniProt (P41145) Pfam (PF00001) | Homo sapiens (human) | K-OR-1,KOR-1 |
| 2 | B (D) | Nanobody39 | polymer | 123 | 13571.0 | 1 | Lama glama | ||
| 3 | C (E) | Soluble cytochrome b562 | polymer | 109 | 12090.5 | 1 | UniProt (P0ABE7) Pfam (PF07361) | Escherichia coli | Cytochrome b-562 |
| 4 | D (A) | nalfurafine | non-polymer | 476.6 | 1 | Chemie (IVB) |
Sequence modifications
A: 54 - 358 (UniProt: P41145)
E: 1001 - 1106 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Leu 135 | Ile 135 | engineered mutation |
| Cys 324 | Ser 324 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 1000 | - | initiating methionine |
| Trp 1007 | Met 29 | engineered mutation |
| Glu 1084 | Val 106 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | variant |
| Gly 1107 | - | linker |
| Ser 1108 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60348.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 476.6 | |
| All* | Total formula weight | 60825.4 |
