7YGQ
Crystal structure of SARS main protease in complex with inhibitor YH-53
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3C-like proteinase nsp5 | polymer | 299 | 33194.9 | 2 | UniProt (P0C6U8) Pfam (PF05409) | Severe acute respiratory syndrome-related coronavirus | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | C, D (A, B) | N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | non-polymer | 575.7 | 2 | Chemie (HUR) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 299 (UniProt: P0C6U8)
| PDB | External Database | Details |
|---|---|---|
| Gln 300 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66389.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1151.4 | |
| All* | Total formula weight | 67541.1 |
