7YGG

Crystal structure of human CD47 in complex with engineered SIRPa.D1(N80A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	SIRPA protein	polymer	142	15261.1	2	Pfam (PF07686) UniProt (by SIFTS) (P78324)	Homo sapiens (human)
2	C, D (C, D)	Leukocyte surface antigen CD47	polymer	125	14245.0	2	UniProt (Q08722) Pfam (PF08204)	Homo sapiens (human)	Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6
3	E, H, K (A, C, D)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4	F, G, I, J (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	L, M, N, O (A, B, C, D)	water	water		18.0	144	Chemie (HOH)

Sequence modifications

C, D: 1 - 117 (UniProt: Q08722)

PDB	External Database	Details
Gly 15	Cys 33	conflict
Thr 118	-	expression tag
Arg 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	59012.3
Non-Polymers*	Number of molecules	7
	Total formula weight	1071.0
All*	Total formula weight	60083.3

*Water molecules are not included.