7YG4

Structure of WTAP-VIRMA in the m6A writer complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein virilizer homolog	polymer	1107	123716.0	1	UniProt (Q69YN4)	Homo sapiens (human)
2	B, C (B, E)	Pre-mRNA-splicing regulator WTAP	polymer	295	34107.2	2	UniProt (Q15007) Pfam (PF17098)	Homo sapiens (human)	Female-lethal(2)D homolog,hFL(2)D,WT1-associated protein,Wilms tumor 1-associating protein

Sequence modifications

A: 381 - 1486 (UniProt: Q69YN4)

PDB	External Database	Details
Met 380	-	initiating methionine

B, E: 1 - 273 (UniProt: Q15007)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Asp -8	-	expression tag
Glu -7	-	expression tag
Val -6	-	expression tag
Asp -5	-	expression tag
Ala -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	191930.4
All*	Total formula weight	191930.4

*Water molecules are not included.