7YFH
Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine, glutamate and (R)-PYD-106
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Glutamate receptor ionotropic, NMDA 1 | polymer | 866 | 97574.6 | 2 | UniProt (P35439) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B, D (B, D) | Glutamate receptor ionotropic, NMDA 2C | polymer | 800 | 87753.8 | 2 | UniProt (Q00961) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluN2C,Glutamate [NMDA] receptor subunit epsilon-3,N-methyl D-aspartate receptor subtype 2C,NMDAR2C,NR2C |
| 3 | E, F, G, L, S (E, H, K, b, y) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G62182OO) | |||
| 4 | H, I, J, K, M... (N, P, T, W, e...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 5 | AA, BA, EA, FA, GA... (B, C, D, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) | |||
| 6 | JA, Z (C, A) | GLYCINE | non-polymer | 75.1 | 2 | Chemie (GLY) PubChem (750) | |||
| 7 | CA, MA (B, D) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) | |||
| 8 | DA (B) | methyl 4-[(2~{R})-3-ethanoyl-1-[2-(2-methyl-1~{H}-indol-3-yl)ethyl]-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-2-yl]benzoate | non-polymer | 432.5 | 1 | Chemie (IWB) |
Sequence modifications
A, C: 1 - 847 (UniProt: P35439)
| PDB | External Database | Details |
|---|---|---|
| Leu 848 | - | expression tag |
| Glu 849 | - | expression tag |
| Val 850 | - | expression tag |
| Leu 851 | - | expression tag |
| Phe 852 | - | expression tag |
| Gln 853 | - | expression tag |
| Gly 854 | - | expression tag |
| Pro 855 | - | expression tag |
| Ala 856 | - | expression tag |
| Ala 857 | - | expression tag |
| Ala 858 | - | expression tag |
| His 859 | - | expression tag |
| His 860 | - | expression tag |
| His 861 | - | expression tag |
| His 862 | - | expression tag |
| His 863 | - | expression tag |
| His 864 | - | expression tag |
| His 865 | - | expression tag |
| His 866 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 370656.8 | |
| Branched | Number of molecules | 17 |
| Total formula weight | 8025.5 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3752.6 | |
| All* | Total formula weight | 382434.9 |
