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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7YFD

Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Engineered G-alpha-qpolymer36141724.41Pfam (PF00503)
UniProt (by SIFTS) (P63092)
UniProt (by SIFTS) (P63096)		Homo sapiens
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer38842282.21UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(C)		scFv16polymer25927784.91Mus musculus
4D
(R)		Histamine H4 receptorpolymer54862137.71UniProt (Q9H3N8)
Pfam (PF00001)		Homo sapiens (human)H4R,HH4R,AXOR35,G-protein coupled receptor 105,GPRv53,Pfi-013,SP9144
5E
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
6F
(N)		Nb35polymer12914016.61Lama glama
7G
(R)		2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioatenon-polymer170.21Chemie (ITF)
8H, I
(R)		CHOLESTEROLnon-polymer386.72Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -21-initiating methionine
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
R: 1 - 390 (UniProt: Q9H3N8)
PDBExternal DatabaseDetails
Val 391-expression tag
Phe 392-expression tag
Thr 393-expression tag
Leu 394-expression tag
Glu 395-expression tag
Asp 396-expression tag
Phe 397-expression tag
Val 398-expression tag
Gly 399-expression tag
Asp 400-expression tag
Trp 401-expression tag
Glu 402-expression tag
Gln 403-expression tag
Thr 404-expression tag
Ala 405-expression tag
Ala 406-expression tag
Tyr 407-expression tag
Asn 408-expression tag
Leu 409-expression tag
Asp 410-expression tag
Gln 411-expression tag
Val 412-expression tag
Leu 413-expression tag
Glu 414-expression tag
Gln 415-expression tag
Gly 416-expression tag
Gly 417-expression tag
Val 418-expression tag
Ser 419-expression tag
Ser 420-expression tag
Leu 421-expression tag
Leu 422-expression tag
Gln 423-expression tag
Asn 424-expression tag
Leu 425-expression tag
Ala 426-expression tag
Val 427-expression tag
Ser 428-expression tag
Val 429-expression tag
Thr 430-expression tag
Pro 431-expression tag
Ile 432-expression tag
Gln 433-expression tag
Arg 434-expression tag
Ile 435-expression tag
Val 436-expression tag
Arg 437-expression tag
Ser 438-expression tag
Gly 439-expression tag
Glu 440-expression tag
Asn 441-expression tag
Ala 442-expression tag
Leu 443-expression tag
Lys 444-expression tag
Ile 445-expression tag
Asp 446-expression tag
Ile 447-expression tag
His 448-expression tag
Val 449-expression tag
Ile 450-expression tag
Ile 451-expression tag
Pro 452-expression tag
Tyr 453-expression tag
Glu 454-expression tag
Gly 455-expression tag
Leu 456-expression tag
Ser 457-expression tag
Ala 458-expression tag
Asp 459-expression tag
Gln 460-expression tag
Met 461-expression tag
Ala 462-expression tag
Gln 463-expression tag
Ile 464-expression tag
Glu 465-expression tag
Glu 466-expression tag
Val 467-expression tag
Phe 468-expression tag
Lys 469-expression tag
Val 470-expression tag
Val 471-expression tag
Tyr 472-expression tag
Pro 473-expression tag
Val 474-expression tag
Asp 475-expression tag
Asp 476-expression tag
His 477-expression tag
His 478-expression tag
Phe 479-expression tag
Lys 480-expression tag
Val 481-expression tag
Ile 482-expression tag
Leu 483-expression tag
Pro 484-expression tag
Tyr 485-expression tag
Gly 486-expression tag
Thr 487-expression tag
Leu 488-expression tag
Val 489-expression tag
Ile 490-expression tag
Asp 491-expression tag
Gly 492-expression tag
Val 493-expression tag
Thr 494-expression tag
Pro 495-expression tag
Asn 496-expression tag
Met 497-expression tag
Leu 498-expression tag
Asn 499-expression tag
Tyr 500-expression tag
Phe 501-expression tag
Gly 502-expression tag
Arg 503-expression tag
Pro 504-expression tag
Tyr 505-expression tag
Glu 506-expression tag
Gly 507-expression tag
Ile 508-expression tag
Ala 509-expression tag
Val 510-expression tag
Phe 511-expression tag
Asp 512-expression tag
Gly 513-expression tag
Lys 514-expression tag
Lys 515-expression tag
Ile 516-expression tag
Thr 517-expression tag
Val 518-expression tag
Thr 519-expression tag
Gly 520-expression tag
Thr 521-expression tag
Leu 522-expression tag
Trp 523-expression tag
Asn 524-expression tag
Gly 525-expression tag
Asn 526-expression tag
Lys 527-expression tag
Ile 528-expression tag
Ile 529-expression tag
Asp 530-expression tag
Glu 531-expression tag
Arg 532-expression tag
Leu 533-expression tag
Ile 534-expression tag
Thr 535-expression tag
Pro 536-expression tag
Asp 537-expression tag
Gly 538-expression tag
Ser 539-expression tag
Met 540-expression tag
Leu 541-expression tag
Phe 542-expression tag
Arg 543-expression tag
Val 544-expression tag
Thr 545-expression tag
Ile 546-expression tag
Asn 547-expression tag
Ser 548-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight195806.9
Non-Polymers*Number of molecules3
Total formula weight943.5
All*Total formula weight196750.5
*Water molecules are not included.

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PDB entries from 2026-04-01

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