7YFD
Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Engineered G-alpha-q | polymer | 361 | 41724.4 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) UniProt (by SIFTS) (P63096) In PDB | Homo sapiens | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 388 | 42282.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
4 | R | Histamine H4 receptor | polymer | 548 | 62137.7 | 1 | UniProt (Q9H3N8) Pfam (PF00001) In PDB | Homo sapiens (human) | H4R,HH4R,AXOR35,G-protein coupled receptor 105,GPRv53,Pfi-013,SP9144 |
5 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
6 | N | Nb35 | polymer | 129 | 14016.6 | 1 | Lama glama | ||
7 | R | 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate | non-polymer | 170.2 | 1 | Chemie (ITF) | |||
8 | R | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: 1 - 390 (UniProt: Q9H3N8)
PDB | External Database | Details |
---|---|---|
Met -21 | - | initiating methionine |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Val 391 | - | expression tag |
Phe 392 | - | expression tag |
Thr 393 | - | expression tag |
Leu 394 | - | expression tag |
Glu 395 | - | expression tag |
Asp 396 | - | expression tag |
Phe 397 | - | expression tag |
Val 398 | - | expression tag |
Gly 399 | - | expression tag |
Asp 400 | - | expression tag |
Trp 401 | - | expression tag |
Glu 402 | - | expression tag |
Gln 403 | - | expression tag |
Thr 404 | - | expression tag |
Ala 405 | - | expression tag |
Ala 406 | - | expression tag |
Tyr 407 | - | expression tag |
Asn 408 | - | expression tag |
Leu 409 | - | expression tag |
Asp 410 | - | expression tag |
Gln 411 | - | expression tag |
Val 412 | - | expression tag |
Leu 413 | - | expression tag |
Glu 414 | - | expression tag |
Gln 415 | - | expression tag |
Gly 416 | - | expression tag |
Gly 417 | - | expression tag |
Val 418 | - | expression tag |
Ser 419 | - | expression tag |
Ser 420 | - | expression tag |
Leu 421 | - | expression tag |
Leu 422 | - | expression tag |
Gln 423 | - | expression tag |
Asn 424 | - | expression tag |
Leu 425 | - | expression tag |
Ala 426 | - | expression tag |
Val 427 | - | expression tag |
Ser 428 | - | expression tag |
Val 429 | - | expression tag |
Thr 430 | - | expression tag |
Pro 431 | - | expression tag |
Ile 432 | - | expression tag |
Gln 433 | - | expression tag |
Arg 434 | - | expression tag |
Ile 435 | - | expression tag |
Val 436 | - | expression tag |
Arg 437 | - | expression tag |
Ser 438 | - | expression tag |
Gly 439 | - | expression tag |
Glu 440 | - | expression tag |
Asn 441 | - | expression tag |
Ala 442 | - | expression tag |
Leu 443 | - | expression tag |
Lys 444 | - | expression tag |
Ile 445 | - | expression tag |
Asp 446 | - | expression tag |
Ile 447 | - | expression tag |
His 448 | - | expression tag |
Val 449 | - | expression tag |
Ile 450 | - | expression tag |
Ile 451 | - | expression tag |
Pro 452 | - | expression tag |
Tyr 453 | - | expression tag |
Glu 454 | - | expression tag |
Gly 455 | - | expression tag |
Leu 456 | - | expression tag |
Ser 457 | - | expression tag |
Ala 458 | - | expression tag |
Asp 459 | - | expression tag |
Gln 460 | - | expression tag |
Met 461 | - | expression tag |
Ala 462 | - | expression tag |
Gln 463 | - | expression tag |
Ile 464 | - | expression tag |
Glu 465 | - | expression tag |
Glu 466 | - | expression tag |
Val 467 | - | expression tag |
Phe 468 | - | expression tag |
Lys 469 | - | expression tag |
Val 470 | - | expression tag |
Val 471 | - | expression tag |
Tyr 472 | - | expression tag |
Pro 473 | - | expression tag |
Val 474 | - | expression tag |
Asp 475 | - | expression tag |
Asp 476 | - | expression tag |
His 477 | - | expression tag |
His 478 | - | expression tag |
Phe 479 | - | expression tag |
Lys 480 | - | expression tag |
Val 481 | - | expression tag |
Ile 482 | - | expression tag |
Leu 483 | - | expression tag |
Pro 484 | - | expression tag |
Tyr 485 | - | expression tag |
Gly 486 | - | expression tag |
Thr 487 | - | expression tag |
Leu 488 | - | expression tag |
Val 489 | - | expression tag |
Ile 490 | - | expression tag |
Asp 491 | - | expression tag |
Gly 492 | - | expression tag |
Val 493 | - | expression tag |
Thr 494 | - | expression tag |
Pro 495 | - | expression tag |
Asn 496 | - | expression tag |
Met 497 | - | expression tag |
Leu 498 | - | expression tag |
Asn 499 | - | expression tag |
Tyr 500 | - | expression tag |
Phe 501 | - | expression tag |
Gly 502 | - | expression tag |
Arg 503 | - | expression tag |
Pro 504 | - | expression tag |
Tyr 505 | - | expression tag |
Glu 506 | - | expression tag |
Gly 507 | - | expression tag |
Ile 508 | - | expression tag |
Ala 509 | - | expression tag |
Val 510 | - | expression tag |
Phe 511 | - | expression tag |
Asp 512 | - | expression tag |
Gly 513 | - | expression tag |
Lys 514 | - | expression tag |
Lys 515 | - | expression tag |
Ile 516 | - | expression tag |
Thr 517 | - | expression tag |
Val 518 | - | expression tag |
Thr 519 | - | expression tag |
Gly 520 | - | expression tag |
Thr 521 | - | expression tag |
Leu 522 | - | expression tag |
Trp 523 | - | expression tag |
Asn 524 | - | expression tag |
Gly 525 | - | expression tag |
Asn 526 | - | expression tag |
Lys 527 | - | expression tag |
Ile 528 | - | expression tag |
Ile 529 | - | expression tag |
Asp 530 | - | expression tag |
Glu 531 | - | expression tag |
Arg 532 | - | expression tag |
Leu 533 | - | expression tag |
Ile 534 | - | expression tag |
Thr 535 | - | expression tag |
Pro 536 | - | expression tag |
Asp 537 | - | expression tag |
Gly 538 | - | expression tag |
Ser 539 | - | expression tag |
Met 540 | - | expression tag |
Leu 541 | - | expression tag |
Phe 542 | - | expression tag |
Arg 543 | - | expression tag |
Val 544 | - | expression tag |
Thr 545 | - | expression tag |
Ile 546 | - | expression tag |
Asn 547 | - | expression tag |
Ser 548 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 195806.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 943.5 | |
All* | Total formula weight | 196750.5 |