7YEG

SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Spike glycoprotein	polymer	1208	133781.3	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	E, J, M	Angiotensin-converting enzyme 2	polymer	597	69153.7	3	UniProt (Q9BYF1) Pfam (PF01401) In PDB	Homo sapiens (human)	Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15
3	H, G, N	heavy chain of R1-32 Fab	polymer	228	23840.7	3		Homo sapiens
4	L, I, O	light chain of R1-32 Fab	polymer	214	22382.6	3		Homo sapiens
5	D, F, K, P, Q...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
6	B, M, C, E, A...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	36	Chemie (NAG)
7	M, E, J	ZINC ION	non-polymer		65.4	3	Chemie (ZN)

Sequence modifications

A, B, C: 1 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 682	Arg 682	engineered mutation
Ser 683	Arg 683	engineered mutation
Ser 685	Arg 685	engineered mutation
Pro 817	Phe 817	engineered mutation
Pro 892	Ala 892	engineered mutation
Pro 899	Ala 899	engineered mutation
Pro 942	Ala 942	engineered mutation
Pro 986	Lys 986	engineered mutation
Pro 987	Val 987	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	747475.0
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	39
	Total formula weight	8159.7
All*	Total formula weight	758181.1

*Water molecules are not included.