7YDG

Crystal structure of human SARS2 catalytic domain with a disease related mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Serine--tRNA ligase, mitochondrial	polymer	355	39409.8	4	UniProt (Q9NP81) Pfam (PF00587) In PDB	Homo sapiens (human)	SerRSmt,Seryl-tRNA synthetase,SerRS,Seryl-tRNA(Ser/Sec) synthetase

Sequence modifications

A, B, C, D: 181 - 522 (UniProt: Q9NP81)

PDB	External Database	Details
Met 168	-	initiating methionine
Gly 169	-	expression tag
Ser 170	-	expression tag
Ser 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
Ser 178	-	expression tag
Ser 179	-	expression tag
Gly 180	-	expression tag
Asn 218	-	insertion
Leu 219	-	insertion
Ser 220	-	insertion
Pro 221	-	insertion
Arg 222	Lys 218	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	157639.3
All*	Total formula weight	157639.3

*Water molecules are not included.