Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrator complex subunit 1 | polymer | 2190 | 244574.9 | 1 | UniProt (Q8N201) Pfam (PF12432) Pfam (PF22929) Pfam (PF22927) Pfam (PF22928) | Homo sapiens (human) | Int1 |
| 2 | B (B) | Integrator complex subunit 2 | polymer | 1204 | 134451.6 | 1 | UniProt (Q9H0H0) Pfam (PF14750) | Homo sapiens (human) | Int2 |
| 3 | C (D) | Integrator complex subunit 4 | polymer | 963 | 108306.8 | 1 | UniProt (Q96HW7) Pfam (PF20168) Pfam (PF13646) | Homo sapiens (human) | Int4 |
| 4 | D (E) | Integrator complex subunit 5 | polymer | 1019 | 108115.2 | 1 | UniProt (Q6P9B9) Pfam (PF14837) Pfam (PF14838) | Homo sapiens (human) | Int5 |
| 5 | E (F) | Integrator complex subunit 6 | polymer | 887 | 100527.1 | 1 | UniProt (Q9UL03) Pfam (PF13519) Pfam (PF15300) | Homo sapiens (human) | Int6,DBI-1,Protein DDX26,Protein deleted in cancer 1,DICE1 |
| 6 | F (G) | Integrator complex subunit 7 | polymer | 962 | 106952.6 | 1 | UniProt (Q9NVH2) Pfam (PF22965) | Homo sapiens (human) | Int7 |
| 7 | G (H) | Integrator complex subunit 8 | polymer | 995 | 113219.9 | 1 | UniProt (Q75QN2) | Homo sapiens (human) | Int8,Protein kaonashi-1 |
| 8 | H (I) | Integrator complex subunit 9 | polymer | 658 | 73891.2 | 1 | UniProt (Q9NV88) Pfam (PF16661) Pfam (PF10996) Pfam (PF21382) | Homo sapiens (human) | Int9,Protein related to CPSF subunits of 74 kDa,RC-74 |
| 9 | I (K) | Integrator complex subunit 11 | polymer | 600 | 67756.6 | 1 | UniProt (Q5TA45) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF21386) | Homo sapiens (human) | Int11,Cleavage and polyadenylation-specific factor 3-like protein,CPSF3-like protein,Protein related to CPSF subunits of 68 kDa,RC-68 |
| 10 | J (M) | Unknown2 | polymer | 17 | 1464.8 | 1 | Homo sapiens | ||
| 11 | K (P) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 589 | 65378.3 | 1 | UniProt (P30153) Pfam (PF02985) | Homo sapiens (human) | Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha |
| 12 | L (Q) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35636.2 | 1 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | PP2A-alpha,Replication protein C,RP-C |
| 13 | M (U) | Unknown | polymer | 27 | 2315.8 | 1 | Homo sapiens | ||
| 14 | N (1) | DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, CTD1, CTD2, CTD3, CTD4 | polymer | 1970 | 217220.1 | 1 | UniProt (P24928) Pfam (PF04997) Pfam (PF05001) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) | Homo sapiens (human) | RNA polymerase II subunit B1,DNA-directed RNA polymerase II subunit A,DNA-directed RNA polymerase III largest subunit,RNA-directed RNA polymerase II subunit RPB1 |
| 15 | O (2) | DNA-directed RNA polymerase subunit beta | polymer | 1174 | 134041.4 | 1 | UniProt (A0A4X1TVZ5) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) UniProt (by SIFTS) (I3LGP4) | Sus scrofa (pig) | |
| 16 | P (3) | DNA-directed RNA polymerase II subunit RPB3 | polymer | 271 | 30997.6 | 1 | UniProt (A0A481DF93) Pfam (PF01193) Pfam (PF01000) UniProt (by SIFTS) (I3LCH3) | Sus scrofa (pig) | |
| 17 | Q (4) | DNA-directed RNA polymerase II subunit E | polymer | 210 | 24644.3 | 1 | UniProt (A0A4X1VTX4) Pfam (PF03871) Pfam (PF01191) UniProt (by SIFTS) (I3LSI7) | Sus scrofa (pig) | RPB5 homolog |
| 18 | R (5) | DNA-directed RNA polymerase II subunit F | polymer | 127 | 14477.0 | 1 | UniProt (A0A4X1VEK9) Pfam (PF01192) | Sus scrofa (pig) | DNA-directed RNA polymerases I,II,and III subunit RPABC2,RPB6 homolog |
| 19 | S (6) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (A0A4X1ULF2) Pfam (PF03870) UniProt (by SIFTS) (I3LCB2) | Sus scrofa (pig) | |
| 20 | T (7) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) Pfam (PF02150) Pfam (PF01096) | Sus scrofa (pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
| 21 | U (8) | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (A0A493TD97) Pfam (PF01194) UniProt (by SIFTS) (A0A8W4F9W9) | Sus scrofa (pig) | |
| 22 | V (9) | RNA_pol_L_2 domain-containing protein | polymer | 117 | 13310.3 | 1 | UniProt (A0A4X1UK25) Pfam (PF13656) UniProt (by SIFTS) (F1RKE4) | Sus scrofa (pig) | |
| 23 | W (a) | RPB12 | polymer | 58 | 7018.2 | 1 | UniProt (A0A4X1TRS6) Pfam (PF03604) | Sus scrofa (pig) | |
| 24 | X (b) | non-template DNA | polymer | 48 | 14932.5 | 1 | synthetic construct | ||
| 25 | Y (c) | RNA | polymer | 23 | 7432.6 | 1 | synthetic construct | ||
| 26 | Z (d) | template DNA | polymer | 48 | 14657.3 | 1 | synthetic construct | ||
| 27 | AA (e) | Negative elongation factor A | polymer | 528 | 57343.6 | 1 | UniProt (Q9H3P2) | Homo sapiens (human) | NELF-A,Wolf-Hirschhorn syndrome candidate 2 protein |
| 28 | BA (f) | Negative elongation factor B | polymer | 580 | 65779.2 | 1 | UniProt (Q8WX92) Pfam (PF06209) | Homo sapiens (human) | NELF-B,Cofactor of BRCA1 |
| 29 | CA (g) | Negative elongation factor C/D | polymer | 590 | 66315.4 | 1 | UniProt (Q8IXH7) Pfam (PF04858) | Homo sapiens (human) | NELF-C/D,TH1-like protein |
| 30 | DA (h) | Negative elongation factor E | polymer | 380 | 43320.9 | 1 | UniProt (P18615) Pfam (PF00076) | Homo sapiens (human) | NELF-E,RNA-binding protein RD |
| 31 | EA (i) | Transcription elongation factor SPT4 | polymer | 121 | 13508.5 | 1 | UniProt (P63272) Pfam (PF06093) | Homo sapiens (human) | hSPT4,DRB sensitivity-inducing factor 14 kDa subunit,DSIF p14,DRB sensitivity-inducing factor small subunit,DSIF small subunit |
| 32 | FA (j) | Transcription elongation factor SPT5 | polymer | 1087 | 121145.5 | 1 | UniProt (O00267) Pfam (PF11942) Pfam (PF03439) Pfam (PF00467) | Homo sapiens (human) | hSPT5,DRB sensitivity-inducing factor 160 kDa subunit,DSIF p160,DRB sensitivity-inducing factor large subunit,DSIF large subunit,Tat-cotransactivator 1 protein,Tat-CT1 protein |
| 33 | GA (k) | DNA-directed RNA polymerase II subunit RPB7 | polymer | 172 | 19314.3 | 1 | UniProt (A0A4X1VKG7) Pfam (PF03876) Pfam (PF00575) | Sus scrofa (pig) | |
| 34 | HA (l) | DNA-directed RNA polymerase II subunit RPB4 | polymer | 142 | 16331.3 | 1 | UniProt (A0A481BYI6) Pfam (PF03874) UniProt (by SIFTS) (A0A4X1VM56) | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit RPB4 isoform X1 |
| 35 | IA, JA, NA, OA, PA... (K, 1, 2, 3, 7...) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 36 | KA, LA (Q) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 37 | MA (1) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
1: 1 - 1699 (UniProt: P24928)
1: 1700 - 1703 (PDB: 7YCX)
1: 1704 - 1856 (UniProt: P24928)
1: 1857 - 1864 (PDB: 7YCX)
1: 1865 - 1970 (UniProt: P24928)
i: 1 - 117 (UniProt: P63272)
1: 1700 - 1703 (PDB: 7YCX)
1: 1704 - 1856 (UniProt: P24928)
1: 1857 - 1864 (PDB: 7YCX)
1: 1865 - 1970 (UniProt: P24928)
i: 1 - 117 (UniProt: P63272)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 34 |
| Total formula weight | 2083739.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 788.3 | |
| All* | Total formula weight | 2084527.8 |
