7YBH

SARS-CoV-2 lambda variant spike

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Spike glycoprotein	polymer	1266	140478.5	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	b, D, E, f, I...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
3	a, c, d, e, F...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	15	In PDB GlyTouCan (G15407YE)
4	J	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
5	A, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	17	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 1266 (UniProt: P0DTC2)

PDB	External Database	Details
Val 75	Gly 75	variant
Ile 76	Thr 76	variant
-	Arg 246	deletion
-	Ser 247	deletion
-	Tyr 248	deletion
-	Leu 249	deletion
-	Thr 250	deletion
-	Pro 251	deletion
-	Gly 252	deletion
Asn 246	Asp 253	variant
Gln 445	Leu 452	variant
Ser 483	Phe 490	variant
Gly 607	Asp 614	variant
Pro 810	Phe 817	engineered mutation
Asn 852	Thr 859	variant
Pro 885	Ala 892	engineered mutation
Pro 892	Ala 899	engineered mutation
Pro 935	Ala 942	engineered mutation
Pro 979	Lys 986	engineered mutation
Pro 980	Val 987	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	421435.5
Branched	Number of molecules	31
	Total formula weight	15912.8
Non-Polymers*	Number of molecules	17
	Total formula weight	3760.5
All*	Total formula weight	441108.9

*Water molecules are not included.