7YA5
Crystal structure analysis of cp1 bound BCL2/G101V
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Apoptosis regulator Bcl-2 | polymer | 166 | 19399.6 | 1 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | |
| 2 | B (B) | cp1 peptide | polymer | 12 | 1361.5 | 1 | synthetic construct | ||
| 3 | C (B) | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid | non-polymer | 488.0 | 1 | Chemie (JFF) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 1 - 75 (UniProt: P10415)
A: 92 - 207 (UniProt: P10415)
A: 92 - 207 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Asp 76 | - | linker |
| Val 77 | - | linker |
| Glu 78 | - | linker |
| Glu 79 | - | linker |
| Asn 80 | - | linker |
| Arg 81 | - | linker |
| Thr 82 | - | linker |
| Glu 83 | - | linker |
| Ala 84 | - | linker |
| Pro 85 | - | linker |
| Glu 86 | - | linker |
| Gly 87 | - | linker |
| Thr 88 | - | linker |
| Glu 89 | - | linker |
| Ser 90 | - | linker |
| Glu 91 | - | linker |
| Val 101 | Gly 101 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20761.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 488.0 | |
| All* | Total formula weight | 21249.1 |
