7Y8G
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with an Inhibitor 30a and GRIP Peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Estrogen receptor | polymer | 260 | 29081.1 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | C, D | Grip peptide | polymer | 8 | 965.2 | 2 | UniProt (by SIFTS) (Q15788) In PDB | Homo sapiens | |
3 | A, B | [4-(1,2,4-triazol-1-yl)phenyl] (1~{S},2~{R},4~{S})-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate | non-polymer | 503.5 | 2 | Chemie (IAT) | |||
4 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
5 | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A, B: 305 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Ala 295 | - | linker |
Gly 296 | - | linker |
Ala 297 | - | linker |
Gly 298 | - | linker |
Ala 299 | - | linker |
Gly 300 | - | linker |
Ala 301 | - | linker |
Gly 302 | - | linker |
Ala 303 | - | linker |
Gly 304 | - | linker |
Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 60092.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1219.3 | |
All* | Total formula weight | 61311.9 |