7Y46
Cryo-EM structure of the Na+,K+-ATPase in the E2.2K+ state after addition of ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (C, A) | Na, K-ATPase alpha subunit | polymer | 1028 | 113309.9 | 2 | UniProt (Q4H132) | Squalus acanthias (spiny dogfish) | |
| 2 | B, E (D, B) | Na+,K+-ATPase beta subunit | polymer | 305 | 35176.1 | 2 | UniProt (C4IX13) | Squalus acanthias (spiny dogfish) | Sodium/potassium-transporting ATPase subunit beta-1 |
| 3 | C, F (E, G) | FXYD domain-containing ion transport regulator | polymer | 94 | 10195.8 | 2 | UniProt (Q70Q12) | Squalus acanthias (spiny dogfish) | |
| 4 | G, K (F, K) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 2 | In PDB GlyTouCan (G82348BZ) | |||
| 5 | H, L (H, L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 2 | In PDB GlyTouCan (G61751GZ) | |||
| 6 | I, M (I, M) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 2 | In PDB GlyTouCan (G42466VF) | |||
| 7 | J, N (J, N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | O, X (C, A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 9 | AA, P, Q, R, Y... (A, C) | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 10 | BA, CA, EA, FA, S... (A, B, C, D) | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) | |||
| 11 | DA, U (A, C) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 2 | Chemie (PCW) | |||
| 12 | GA, HA (C, A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 317363.7 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 6980.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 5916.4 | |
| All* | Total formula weight | 330260.6 |
