7Y24
Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 224 | 25056.6 | 1 | UniProt (P09471) Pfam (PF00503) In PDB | Homo sapiens (human) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 338 | 37198.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 56 | 6160.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | S | single Fab chain (svFv16) | polymer | 246 | 26222.2 | 1 | Homo sapiens (human) | ||
5 | C | Octreotide | polymer | 8 | 1036.2 | 1 | Homo sapiens | ||
6 | E | Somatostatin receptor type 2 | polymer | 327 | 36740.6 | 1 | UniProt (P30874) Pfam (PF00001) In PDB | Homo sapiens (human) | SS-2-R,SS2-R,SS2R,SST2,SRIF-1 |
Sequence modifications
A: 5 - 173 (UniProt: P09471)
A: 182 - 231 (UniProt: P09471)
A: 242 - 354 (UniProt: P09471)
PDB | External Database | Details |
---|---|---|
Asp 42 | Gly 42 | engineered mutation |
Asn 43 | Glu 43 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 174 | - | linker |
Gly 175 | - | linker |
Ser 176 | - | linker |
Gly 177 | - | linker |
Gly 178 | - | linker |
Ser 179 | - | linker |
Gly 180 | - | linker |
Gly 181 | - | linker |
Asp 227 | Ala 227 | engineered mutation |
Asp 230 | Gly 230 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asp 250 | Leu 250 | engineered mutation |
Ala 332 | Ile 332 | engineered mutation |
Ile 335 | Val 335 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 132414.4 | |
All* | Total formula weight | 132414.4 |