7XZ6

GPR119-Gs-APD668 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	394	45699.4	1	Pfam (PF00503) UniProt (by SIFTS) (P63092)	Homo sapiens (human)
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	345	37915.5	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
4	D (N)	Nanobody35	polymer	139	15271.9	1		Lama glama
5	E (R)	Soluble cytochrome b562,Glucose-dependent insulinotropic receptor	polymer	485	53785.1	1	UniProt (P0ABE7) UniProt (Q8TDV5) Pfam (PF00001)	Escherichia coli	Cytochrome b-562,G-protein coupled receptor 119
6	F (R)	propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate	non-polymer		477.5	1	Chemie (I7J)
7	G (R)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -4	-	initiating methionine
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag

R: -121 - -17 (UniProt: P0ABE7)

PDB	External Database	Details
Asp -149	-	expression tag
Tyr -148	-	expression tag
Lys -147	-	expression tag
Asp -146	-	expression tag
Asp -145	-	expression tag
Asp -144	-	expression tag
Asp -143	-	expression tag
Ala -142	-	expression tag
Lys -141	-	expression tag
Leu -140	-	expression tag
Gln -139	-	expression tag
Thr -138	-	expression tag
Met -137	-	expression tag
His -136	-	expression tag
His -135	-	expression tag
His -134	-	expression tag
His -133	-	expression tag
His -132	-	expression tag
His -131	-	expression tag
His -130	-	expression tag
His -129	-	expression tag
His -128	-	expression tag
His -127	-	expression tag
His -126	-	expression tag
His -125	-	expression tag
His -124	-	expression tag
His -123	-	expression tag
His -122	-	expression tag
Trp -115	Met 29	conflict
Ile -20	His 124	conflict
Leu -16	-	linker
Ala -15	-	linker
Ser -14	-	linker
Glu -13	-	linker
Asn -12	-	linker
Leu -11	-	linker
Tyr -10	-	linker
Phe -9	-	linker
Gln -8	-	linker
Gly -7	-	linker
Gly -6	-	linker
Gly -5	-	linker
Gly -4	-	linker
Gly -3	-	linker
Ser -2	-	linker
Gly -1	-	linker
Thr 0	-	linker

R: 1 - 335 (UniProt: Q8TDV5)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	160533.1
Non-Polymers*	Number of molecules	1
	Total formula weight	477.5
All*	Total formula weight	161010.6

*Water molecules are not included.