7XZ6
GPR119-Gs-APD668 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens (human) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody35 | polymer | 139 | 15271.9 | 1 | Lama glama | ||
5 | R | Soluble cytochrome b562,Glucose-dependent insulinotropic receptor | polymer | 485 | 53785.1 | 1 | UniProt (P0ABE7) UniProt (Q8TDV5) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,G-protein coupled receptor 119 |
6 | R | propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate | non-polymer | 477.5 | 1 | Chemie (I7J) | |||
7 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -121 - -17 (UniProt: P0ABE7)
R: 1 - 335 (UniProt: Q8TDV5)
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -149 | - | expression tag |
Tyr -148 | - | expression tag |
Lys -147 | - | expression tag |
Asp -146 | - | expression tag |
Asp -145 | - | expression tag |
Asp -144 | - | expression tag |
Asp -143 | - | expression tag |
Ala -142 | - | expression tag |
Lys -141 | - | expression tag |
Leu -140 | - | expression tag |
Gln -139 | - | expression tag |
Thr -138 | - | expression tag |
Met -137 | - | expression tag |
His -136 | - | expression tag |
His -135 | - | expression tag |
His -134 | - | expression tag |
His -133 | - | expression tag |
His -132 | - | expression tag |
His -131 | - | expression tag |
His -130 | - | expression tag |
His -129 | - | expression tag |
His -128 | - | expression tag |
His -127 | - | expression tag |
His -126 | - | expression tag |
His -125 | - | expression tag |
His -124 | - | expression tag |
His -123 | - | expression tag |
His -122 | - | expression tag |
Trp -115 | Met 29 | conflict |
Ile -20 | His 124 | conflict |
Leu -16 | - | linker |
Ala -15 | - | linker |
Ser -14 | - | linker |
Glu -13 | - | linker |
Asn -12 | - | linker |
Leu -11 | - | linker |
Tyr -10 | - | linker |
Phe -9 | - | linker |
Gln -8 | - | linker |
Gly -7 | - | linker |
Gly -6 | - | linker |
Gly -5 | - | linker |
Gly -4 | - | linker |
Gly -3 | - | linker |
Ser -2 | - | linker |
Gly -1 | - | linker |
Thr 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 160533.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 477.5 | |
All* | Total formula weight | 161010.6 |