7XY7
Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 243 | 28146.8 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 366 | 39728.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 73 | 7891.0 | 1 | Pfam (PF00631) UniProt (by SIFTS) (P59768) In PDB | Homo sapiens (human) | |
4 | R | Soluble cytochrome b562,Adenosine receptor A2b,LgBiT | polymer | 628 | 69594.1 | 1 | UniProt (P0ABE7) UniProt (P29275) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562 |
5 | R | N-ETHYL-5'-CARBOXAMIDO ADENOSINE | non-polymer | 308.3 | 1 | Chemie (NEC) |
Sequence modifications
A: 19 - 186 (UniProt: P63092)
A: 197 - 377 (UniProt: P63092)
B: 1 - 340 (UniProt: P62873)
R: -111 - -7 (UniProt: P0ABE7)
R: 2 - 332 (UniProt: P29275)
R: 333 - 495 (PDB: 7XY7)
PDB | External Database | Details |
---|---|---|
Thr 4 | - | expression tag |
Val 5 | - | expression tag |
Ser 6 | - | expression tag |
Ala 7 | - | expression tag |
Glu 8 | - | expression tag |
Asp 9 | - | expression tag |
Lys 10 | - | expression tag |
Ala 11 | - | expression tag |
Ala 12 | - | expression tag |
Ala 13 | - | expression tag |
Glu 14 | - | expression tag |
Arg 15 | - | expression tag |
Ser 16 | - | expression tag |
Lys 17 | - | expression tag |
Met 18 | - | expression tag |
Asp 42 | Gly 49 | engineered mutation |
Asn 43 | Glu 50 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Tyr 187 | - | linker |
His 188 | - | linker |
Gly 189 | - | linker |
Gly 190 | - | linker |
Ser 191 | - | linker |
Gly 192 | - | linker |
Gly 193 | - | linker |
Ser 194 | - | linker |
Gly 195 | - | linker |
Gly 196 | - | linker |
Asp 242 | Ala 249 | engineered mutation |
Asp 245 | Ser 252 | engineered mutation |
- | Asn 254 | deletion |
- | Met 255 | deletion |
- | Val 256 | deletion |
- | Ile 257 | deletion |
- | Arg 258 | deletion |
- | Glu 259 | deletion |
- | Asp 260 | deletion |
- | Asn 261 | deletion |
- | Gln 262 | deletion |
- | Thr 263 | deletion |
Asp 255 | Leu 272 | engineered mutation |
Ala 355 | Ile 372 | engineered mutation |
Ile 358 | Val 375 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -132 | - | expression tag |
Tyr -131 | - | expression tag |
Lys -130 | - | expression tag |
Asp -129 | - | expression tag |
Asp -128 | - | expression tag |
Asp -127 | - | expression tag |
Asp -126 | - | expression tag |
Ala -125 | - | expression tag |
Gly -124 | - | expression tag |
Arg -123 | - | expression tag |
Ala -122 | - | expression tag |
His -121 | - | expression tag |
His -120 | - | expression tag |
His -119 | - | expression tag |
His -118 | - | expression tag |
His -117 | - | expression tag |
His -116 | - | expression tag |
His -115 | - | expression tag |
His -114 | - | expression tag |
His -113 | - | expression tag |
His -112 | - | expression tag |
Trp -105 | Met 29 | engineered mutation |
Ile -10 | His 124 | engineered mutation |
Leu -6 | - | linker |
Glu -5 | - | linker |
Asn -4 | - | linker |
Leu -3 | - | linker |
Tyr -2 | - | linker |
Phe -1 | - | linker |
Gln 0 | - | linker |
Ser 1 | - | linker |
R: 333 - 495 (PDB: 7XY7)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 145360.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 308.3 | |
All* | Total formula weight | 145668.6 |