7XXH
Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | P2Y purinoceptor 1 | polymer | 413 | 46296.9 | 1 | UniProt (P47900) Pfam (PF00001) | Homo sapiens (human) | P2Y1,ADP receptor,Purinergic receptor |
| 2 | B (A) | Guanine nucleotide-binding protein G(11) subunit alpha | polymer | 353 | 41385.3 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P29992) UniProt (by SIFTS) (P63096) | Homo sapiens | |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 346 | 38245.8 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (H) | scfv16 | polymer | 247 | 26337.3 | 1 | Homo sapiens | ||
| 6 | F (R) | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate) | non-polymer | 473.3 | 1 | Chemie (6AD) |
Sequence modifications
R: 2 - 373 (UniProt: P47900)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Glu 374 | - | expression tag |
| Phe 375 | - | expression tag |
| Leu 376 | - | expression tag |
| Glu 377 | - | expression tag |
| Val 378 | - | expression tag |
| Leu 379 | - | expression tag |
| Phe 380 | - | expression tag |
| Gln 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Pro 383 | - | expression tag |
| Gly 384 | - | expression tag |
| Ser 385 | - | expression tag |
| Trp 386 | - | expression tag |
| Ser 387 | - | expression tag |
| His 388 | - | expression tag |
| Pro 389 | - | expression tag |
| Gln 390 | - | expression tag |
| Phe 391 | - | expression tag |
| Glu 392 | - | expression tag |
| Lys 393 | - | expression tag |
| Gly 394 | - | expression tag |
| Ser 395 | - | expression tag |
| Gly 396 | - | expression tag |
| Ala 397 | - | expression tag |
| Gly 398 | - | expression tag |
| Ala 399 | - | expression tag |
| Ser 400 | - | expression tag |
| Ala 401 | - | expression tag |
| Gly 402 | - | expression tag |
| Ser 403 | - | expression tag |
| Trp 404 | - | expression tag |
| Ser 405 | - | expression tag |
| His 406 | - | expression tag |
| Pro 407 | - | expression tag |
| Gln 408 | - | expression tag |
| Phe 409 | - | expression tag |
| Glu 410 | - | expression tag |
| Lys 411 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -5 | - | initiating methionine |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 160126.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 473.3 | |
| All* | Total formula weight | 160599.7 |
