7XWQ
Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-2-(2-chloro-4-hydroxyphenyl)-3-(4-hydroxyphenyl)propanenitrile
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor beta | polymer | 247 | 27702.6 | 2 | UniProt (Q92731) Pfam (PF00104) | Homo sapiens (human) | ER-beta,Nuclear receptor subfamily 3 group A member 2 |
| 2 | C, D (C, D) | SRC peptide | polymer | 13 | 1386.6 | 2 | UniProt (by SIFTS) (Q15788) | Homo sapiens | |
| 3 | E, F (A, B) | (2~{R})-2-(2-chloranyl-4-oxidanyl-phenyl)-3-(4-hydroxyphenyl)propanenitrile | non-polymer | 273.7 | 2 | Chemie (I1M) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A, B: 261 - 500 (UniProt: Q92731)
| PDB | External Database | Details |
|---|---|---|
| Gly 256 | - | expression tag |
| Pro 257 | - | expression tag |
| Leu 258 | - | expression tag |
| Gly 259 | - | expression tag |
| Ser 260 | - | expression tag |
| Ser 334 | Cys 334 | engineered mutation |
| Ser 369 | Cys 369 | engineered mutation |
| Ser 481 | Cys 481 | engineered mutation |
| Asp 501 | - | expression tag |
| Asp 502 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58178.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 547.4 | |
| All* | Total formula weight | 58725.8 |
