7XV3
Cryo-EM structure of LPS-bound GPR174 in complex with Gs protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | R | Probable G-protein coupled receptor 174 | polymer | 333 | 38539.5 | 1 | UniProt (Q9BXC1) Pfam (PF00001) In PDB | Homo sapiens (human) | |
| 2 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 3 | A | Engineered G protein subunit S (mini-Gs) | polymer | 361 | 41879.5 | 1 | Homo sapiens (human) | ||
| 4 | N | Nb35 | polymer | 161 | 17381.6 | 1 | Lama glama | ||
| 5 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 6 | R | (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid | non-polymer | 497.4 | 1 | Chemie (WJS) | |||
| 7 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 143577.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 497.4 | |
| All* | Total formula weight | 144074.6 |
