7XUD
Structure of G9a in complex with compound 26a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase EHMT2 | polymer | 283 | 32604.9 | 2 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
| 2 | C, D, E, F, K... (A, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | H, O (A, B) | SINEFUNGIN | non-polymer | 381.4 | 2 | Chemie (SFG) | |||
| 5 | I, P (A, B) | ~{N}-[(2~{S})-4-cyclopropyl-1-oxidanylidene-1-phenylazanyl-butan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide | non-polymer | 421.5 | 2 | Chemie (I6Z) | |||
| 6 | J, R, S (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 7 | Q (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 8 | T, U (A, B) | water | water | 18.0 | 577 | Chemie (HOH) |
Sequence modifications
A, B: 913 - 1193 (UniProt: Q96KQ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 911 | - | expression tag |
| Ser 912 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65209.8 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2472.9 | |
| All* | Total formula weight | 67682.8 |
